Document Detail


Clinical and laboratory study of rosacea in northern Greece.
MedLine Citation:
PMID:  19744179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Numerous factors have been implicated in the pathogenesis of rosacea, which remains obscure. OBJECTIVES: To examine the epidemiological characteristics of rosacea patients, the histopathological alterations, the prevalence of gastric Helicobacter pylori infection and the role of ultraviolet radiation, to detect the presence of Demodex folliculorum on affected skin and to elucidate the immunological nature of this disorder. METHODS: The study included 100 patients with rosacea. Each patient was assessed with a clinical, haematological, biochemical and histological examination; serology test for the detection of antibodies against H. pylori; direct immunofluorescence on perilesional, sun exposed skin and indirect immunofluorescence with monkey oesophagus as a substrate; antinuclear antibody titre and a skin surface biopsy to search for Demodex folliculorum. RESULTS: Women were more frequently affected. Half of our patients were 51-70 years old. About two-thirds were photo-types I and II and 73% complained of worsening of conditions after sun exposure. An almost permanent histopathological feature was solar elastosis. Higher prevalence of H. pylori was not established. Prevalence and mean density of Demodex folliculorum were significantly increased in rosacea patients. Direct and indirect immunofluorescence tests were positive in 6.4% and 6.7% respectively. Antinuclear antibody titres were found in 21.1%. CONCLUSIONS: Our results suggest the pivotal role of chronic sun exposure in the pathogenesis of rosacea. Demodex folliculorum represents a significant cofactor that may contribute to the transition of the disease from a vascular to an inflammatory stage. The low positive results of direct and indirect immunofluorescence do not support a potential autoimmune role in the development of rosacea.
Authors:
E Lazaridou; Z Apalla; S Sotiraki; N G Ziakas; C Fotiadou; D Ioannides
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Publication Detail:
Type:  Journal Article     Date:  2009-09-08
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  24     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  410-4     Citation Subset:  IM    
Affiliation:
First Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece. bethlaz@med.auth.gr
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MeSH Terms
Descriptor/Qualifier:
Age Distribution
Aged
Animals
Antibodies, Bacterial / blood
Biopsy
Female
Greece / epidemiology
Helicobacter Infections / epidemiology*,  pathology
Helicobacter pylori* / immunology
Humans
Male
Middle Aged
Mite Infestations / epidemiology*,  pathology
Mites / immunology
Prevalence
Risk Factors
Rosacea / classification,  epidemiology*,  pathology
Seroepidemiologic Studies
Sex Distribution
Ultraviolet Rays
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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