Document Detail

Clinical and laboratory study of rosacea in northern Greece.
MedLine Citation:
PMID:  19744179     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Numerous factors have been implicated in the pathogenesis of rosacea, which remains obscure. OBJECTIVES: To examine the epidemiological characteristics of rosacea patients, the histopathological alterations, the prevalence of gastric Helicobacter pylori infection and the role of ultraviolet radiation, to detect the presence of Demodex folliculorum on affected skin and to elucidate the immunological nature of this disorder. METHODS: The study included 100 patients with rosacea. Each patient was assessed with a clinical, haematological, biochemical and histological examination; serology test for the detection of antibodies against H. pylori; direct immunofluorescence on perilesional, sun exposed skin and indirect immunofluorescence with monkey oesophagus as a substrate; antinuclear antibody titre and a skin surface biopsy to search for Demodex folliculorum. RESULTS: Women were more frequently affected. Half of our patients were 51-70 years old. About two-thirds were photo-types I and II and 73% complained of worsening of conditions after sun exposure. An almost permanent histopathological feature was solar elastosis. Higher prevalence of H. pylori was not established. Prevalence and mean density of Demodex folliculorum were significantly increased in rosacea patients. Direct and indirect immunofluorescence tests were positive in 6.4% and 6.7% respectively. Antinuclear antibody titres were found in 21.1%. CONCLUSIONS: Our results suggest the pivotal role of chronic sun exposure in the pathogenesis of rosacea. Demodex folliculorum represents a significant cofactor that may contribute to the transition of the disease from a vascular to an inflammatory stage. The low positive results of direct and indirect immunofluorescence do not support a potential autoimmune role in the development of rosacea.
E Lazaridou; Z Apalla; S Sotiraki; N G Ziakas; C Fotiadou; D Ioannides
Related Documents :
2673049 - Porphyrialike bullous dermatosis after chronic intense tanning bed and/or sunlight expo...
18173609 - Clinical importance of demodex folliculorum in patients receiving phototherapy.
17234649 - The eustar model for teaching and implementing the modified rodnan skin score in system...
10731889 - Effects of vacuum compression therapy on skin microcirculation in patients suffering fr...
19128909 - Prevalence of nephrogenic systemic fibrosis in renal insufficiency patients: results of...
2716769 - Chronic gamma-radiation sensitivity of skin fibroblasts from patients with non-hodgkin'...
8598429 - Enteral nutritional support in acute alcoholic pancreatitis.
22245569 - Clinical study in chinese patients with late-infantile form neuronal ceroid lipofuscino...
22271569 - Excess primary intestinal lymphoproliferative disorders in patients with inflammatory b...
Publication Detail:
Type:  Journal Article     Date:  2009-09-08
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  24     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-14     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  410-4     Citation Subset:  IM    
First Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Distribution
Antibodies, Bacterial / blood
Greece / epidemiology
Helicobacter Infections / epidemiology*,  pathology
Helicobacter pylori* / immunology
Middle Aged
Mite Infestations / epidemiology*,  pathology
Mites / immunology
Risk Factors
Rosacea / classification,  epidemiology*,  pathology
Seroepidemiologic Studies
Sex Distribution
Ultraviolet Rays
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Growth rate of human fingernails and toenails in healthy American young adults.
Next Document:  Soluble immune receptor serum levels are associated with age, but not with clinical phenotype or dis...