| Clinical and laboratory predictors of cholelithiasis in patients with sickle cell anaemia. | |
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MedLine Citation:
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PMID: 9803618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholelithiasis is a common clinical condition in patients with sickle cell disease and there are conflicting reports on laboratory indices useful in predicting those patients who are likely to have gallstones. There is however lack of similar studies from Kenya. We therefore studied the role of clinical (Body Mass Index), haematological (reticulocyte count, haemoglobin level), and biochemical (serum bilirubin: direct and indirect, serum alkaline phosphatase, serum transaminase) indices in predicting sickle cell anaemia patients likely to develop gallstones. A cross sectional descriptive study was conducted from October 1993 to December 1994 on consecutive male and female patients of all ages with homozygous sickle cell disease (HbSS) confirmed by cellulose acetate paper electrophoresis. A total of 64 patients aged between three and 37 years were recruited into the study. They were classified into two groups: stone formers and non-formers. The difference in the two groups with respect to clinical, haematological and biochemical indices were determined by Chi-square contingency test. Body mass index (BMI), reticulocyte count and alkaline phosphatase were found to have a significant positive association with increased likelihood of gallstone formation at p values of 0.004, 0.007 and 0.007, respectively. The rest of the study indices had no association. The cut-off points were reticulocyte counts above ten per cent and alkaline phosphatase levels above 13 K.A. units. Though sickle cell anaemia patients with BMI > 20 had significant increased likelihood of cholelithiasis, we could not determine its cut-off value. |
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Authors:
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E Omonge; E O Ogutu; J R Aluoch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: East African medical journal Volume: 75 ISSN: 0012-835X ISO Abbreviation: East Afr Med J Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-11-23 Completed Date: 1998-11-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372766 Medline TA: East Afr Med J Country: KENYA |
Other Details:
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Languages: eng Pagination: 347-50 Citation Subset: IM |
Affiliation:
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Kiambu District Hospital, Nairobi, Kenya. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alkaline Phosphatase / blood Anemia, Sickle Cell / complications* Body Mass Index Case-Control Studies Chi-Square Distribution Child Child, Preschool Cholelithiasis / blood, diagnosis*, etiology* Cross-Sectional Studies Female Humans Male Predictive Value of Tests Reticulocyte Count |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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