Document Detail


Clinical and laboratory predictors of cholelithiasis in patients with sickle cell anaemia.
MedLine Citation:
PMID:  9803618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cholelithiasis is a common clinical condition in patients with sickle cell disease and there are conflicting reports on laboratory indices useful in predicting those patients who are likely to have gallstones. There is however lack of similar studies from Kenya. We therefore studied the role of clinical (Body Mass Index), haematological (reticulocyte count, haemoglobin level), and biochemical (serum bilirubin: direct and indirect, serum alkaline phosphatase, serum transaminase) indices in predicting sickle cell anaemia patients likely to develop gallstones. A cross sectional descriptive study was conducted from October 1993 to December 1994 on consecutive male and female patients of all ages with homozygous sickle cell disease (HbSS) confirmed by cellulose acetate paper electrophoresis. A total of 64 patients aged between three and 37 years were recruited into the study. They were classified into two groups: stone formers and non-formers. The difference in the two groups with respect to clinical, haematological and biochemical indices were determined by Chi-square contingency test. Body mass index (BMI), reticulocyte count and alkaline phosphatase were found to have a significant positive association with increased likelihood of gallstone formation at p values of 0.004, 0.007 and 0.007, respectively. The rest of the study indices had no association. The cut-off points were reticulocyte counts above ten per cent and alkaline phosphatase levels above 13 K.A. units. Though sickle cell anaemia patients with BMI > 20 had significant increased likelihood of cholelithiasis, we could not determine its cut-off value.
Authors:
E Omonge; E O Ogutu; J R Aluoch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  East African medical journal     Volume:  75     ISSN:  0012-835X     ISO Abbreviation:  East Afr Med J     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-23     Completed Date:  1998-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372766     Medline TA:  East Afr Med J     Country:  KENYA    
Other Details:
Languages:  eng     Pagination:  347-50     Citation Subset:  IM    
Affiliation:
Kiambu District Hospital, Nairobi, Kenya.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alkaline Phosphatase / blood
Anemia, Sickle Cell / complications*
Body Mass Index
Case-Control Studies
Chi-Square Distribution
Child
Child, Preschool
Cholelithiasis / blood,  diagnosis*,  etiology*
Cross-Sectional Studies
Female
Humans
Male
Predictive Value of Tests
Reticulocyte Count
Chemical
Reg. No./Substance:
EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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