Document Detail

Clinical and laboratory management of the prothrombin G20210A mutation.
MedLine Citation:
PMID:  12421139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To make recommendations regarding the appropriate evaluation for the prothrombin G20210A mutation, as reflected by published evidence and the consensus opinion of recognized experts in the field. DAT SOURCES: Review of the medical literature, primarily since 1996. DATA EXTRACTION AND SYNTHESIS: After an initial assessment of the literature, key points defining the condition, and review of the clinical study design, a draft manuscript was prepared and circulated to every participant in the College of American Pathologists Conference on Diagnostic Issues in Thrombophilia before the meeting. Each of the key points and associated recommendations were then presented for discussion at the conference. Recommendations were accepted if a consensus of 70% of experts attending the conference was reached. The results of the discussion were used to revise the manuscript into its final form. CONCLUSIONS: Consensus was reached on several recommendations concerning the criteria for testing for the prothrombin G20210A mutation and for the method of testing. First, a major point of consensus was that the prothrombin G20210A mutation is a significant risk factor for venous thromboembolism (VTE) and that testing should be considered in the initial evaluation of suspected inherited thrombophilia. Second, although several analytic methods are commonly used for genetic testing for the prothrombin mutation, all are generally robust and reliable. The recommendations for testing for the prothrombin mutation parallel those for the factor V Leiden mutation and include patients with a history of recurrent VTE, a first episode of VTE before the age of 50 years, a history of an unprovoked VTE at any age, thromboses in unusual anatomic sites, or an affected first-degree relative with VTE. A history of VTE related to pregnancy or estrogen use and unexplained pregnancy loss during the second or third trimesters were also considered to be indications for testing. Other scenarios remain controversial or not recommended, including general population screening.
Ronald C McGlennen; Nigel S Key
Related Documents :
17080209 - Monitoring unfractionated heparin with the aptt: time for a fresh look.
21671139 - Effects of skewness and kurtosis on normal-theory based maximum likelihood test statist...
8839999 - A new global test for the evaluation of the protein c-protein s system.
1947079 - Current use of screening laboratory tests before abdominal interventions: a survey of 6...
20959659 - Lupus anticoagulant testing: performance and practices by north american clinical labor...
20042979 - Force exertion capacity measurements in haptic virtual environments.
6838439 - The efficacy of some acaricides against screw-worm fly larvae.
7645449 - The timed test of money counting: a short physical performance test for manual dexterit...
3738219 - Operative cholangiography with an antiseptic contrast solution. an experimental study i...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  126     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2002-12-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1319-25     Citation Subset:  AIM; IM    
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Coagulation Tests
Coagulation Protein Disorders / diagnosis*,  epidemiology,  genetics
Genetic Predisposition to Disease
Genetic Testing
Middle Aged
Practice Guidelines as Topic
Pregnancy Complications, Hematologic / diagnosis
Prothrombin / genetics*
Risk Assessment
Risk Factors
Thromboembolism / diagnosis,  epidemiology,  genetics
Thrombophilia / diagnosis,  genetics
Venous Thrombosis / diagnosis,  epidemiology,  genetics
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical utility of factor V leiden (R506Q) testing for the diagnosis and management of thromboembol...
Next Document:  Antithrombin deficiency: issues in laboratory diagnosis.