| Clinical and laboratory features of youth onset type 2 diabetes in Jamaica. | |
| | |
MedLine Citation:
|
PMID: 21275116 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVES: To assess the frequency of youth onset Type 2 diabetes mellitus (T2D) in Jamaica and the characteristics of youth with this form of diabetes. METHODS: Patients from two major referral hospitals, diagnosed with diabetes before age 25 years and < 6 years prior to the study, were evaluated. Classification was based on the presence of GAD-65 and IA-2 diabetes autoantibodies (AB), fasting (FCP) and stimulated C-peptide (SCP) measurements, serum leptin and clinical phenotype as follows: (i) Type IA diabetes--AB+, (ii) Type lB diabetes--AB- and FCP < 230 pmol/l and/or SCP < 660pmol/l, (iii) Type 2 diabetes - AB- and FCP > 500 pmol/L and or SCP 2 1160 pmol/l (iv) Untypeable diabetes--AB- and FCP 230-500 pmol/l and or SCP 660-1160 pmol/l and (v) Lipoatrophic diabetes--clinical phenotype and serum leptin. RESULTS: Fifty-eight participants (21M, 37F, age 20-8 years, duration of diabetes 2.6-2 years) were enrolled in the study. Using the classification criteria, Type 1 diabetes was the most common form of diabetes: 18 (31%) Type 1A, 18 (31%) Type IB. Overall 22% (13 patients) had T2D. Patients with T2D were more likely to be female, older at diagnosis, obese and have a higher blood pressure when compared to those with Type 1 diabetes. In logistic regression analysis, age of diabetes onset, gender BMI, systolic and diastolic blood pressure were significantly associated with T2D. Obesity measured by BMI was the strongest predictor of T2D. CONCLUSIONS: While Type 1 diabetes was the predominant form of diabetes in this study, a significant proportion of Jamaicans with youth onset diabetes may have T2D. Obesity is the strongest clinical predictor of Type 2 diabetes in the young diabetic patient. |
| | |
Authors:
|
M K Tulloch-Reid; M S Boyne; M F Smikle; E G Choo-Kang; R H Parkes; R A Wright-Pascoe; E N Barton; R J Wilks; D E Williams |
Related Documents
:
|
8882536 - Mass screening for diabetic retinopathy--a report on diabetic retinal screening in prim... 10656226 - Population-based genetic screening for the estimation of type 1 diabetes mellitus risk ... 19557386 - Glucose challenge test screening for prediabetes and undiagnosed diabetes. 1880516 - Graded assessment and classification of impaired temperature sensibility in patients wi... 17957036 - Does impaired mitochondrial function affect insulin signaling and action in cultured hu... 9819706 - Accurate detection of smith-lemli-opitz syndrome carriers by measurement of the rate of... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The West Indian medical journal Volume: 59 ISSN: 0043-3144 ISO Abbreviation: West Indian Med J Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2011-01-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0417410 Medline TA: West Indian Med J Country: Jamaica |
Other Details:
|
Languages: eng Pagination: 131-8 Citation Subset: IM |
Affiliation:
|
Tropical Medicine Research Institute, University of the West Indies, Jamaica. marshall.tullochreid@uwimona.edu.jm |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association between anthropometric hormonal measurements and bone mineral density in puberty and con...
Next Document: Knowledge and practice of occupational infection control among healthcare workers in Jamaica.