| Clinical and laboratory features of scleroderma patients with pulmonary hypertension. | |
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MedLine Citation:
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PMID: 11085808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Pulmonary hypertension (PH) is a frequent cause of death in patients with systemic sclerosis (SSc). In this study, we examined the occurrence of PH and investigated the clinical and laboratory features of SSc patients with PH. METHODS: A cross-sectional study of 125 Japanese patients with SSc was conducted using Doppler echocardiography, other multiple cardiopulmonary tests, and laboratory examination. RESULTS: PH (systolic pressure >40 mmHg) was diagnosed in 20 patients (16%) by Doppler echocardiography. In the six patients who had secondary pulmonary hypertension (SPH), PH was due to severe pulmonary fibrosis; 14 patients had isolated pulmonary hypertension (IPH). An elevated erythrocyte sedimentation rate (ESR) and increased immunoglobulin G (IgG) were found in a significantly greater proportion of the patients with PH than in those without PH. The incidence of pitting scars/ulcers was significantly greater in the patients with SPH than in those without PH. CONCLUSION: Elevated ESR and increased IgG were common features of scleroderma patients with PH, and scleroderma patients with SPH were inclined to have pitting scars/ulcers. |
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Authors:
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K Yamane; H Ihn; Y Asano; N Yazawa; M Kubo; K Kikuchi; Y Soma; K Tamaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 39 ISSN: 1462-0324 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-08 Completed Date: 2000-12-22 Revised Date: 2007-09-06 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1269-71 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Blood Sedimentation Cicatrix / epidemiology, ultrasonography Cross-Sectional Studies DNA Topoisomerases, Type I / immunology Echocardiography, Doppler Female Humans Hypertension, Pulmonary / epidemiology*, ultrasonography* Immunoglobulin G / blood Incidence Male Middle Aged Pulmonary Fibrosis / epidemiology, ultrasonography Scleroderma, Systemic / epidemiology*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; EC 5.99.1.2/DNA Topoisomerases, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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