Document Detail

Clinical and laboratory characteristics of children positive for antiphospholipid antibodies.
MedLine Citation:
PMID:  22244004     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It is difficult to estimate the actual prevalence of antiphospholipid syndrome (APS) in the paediatric population since there are no standardised criteria. We aimed to assess clinical and laboratory characteristics of a cohort of children positive for antiphospholipid antibodies (aPL) to contribute to the understanding of the heterogeneous aPL-related features in childhood.
MATERIALS AND METHODS: Forty-four patients with prolonged activated partial thromboplastin time were enrolled and assigned to group I ("transiently positive") or group II ("persistently positive"), based on the detection of elevated aPL plasma levels [lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI) antibodies] on, respectively, one or more occasions, at least 12 weeks apart, by standard procedures. The clinical history and symptoms of all patients were recorded.
RESULTS: Thirty-three (75%) patients were assigned to group I, while the other 11 (25%) formed group II. Major associated diseases in group I were urticarial vasculitis (21%), acute infections (18%) and thalassaemia (12%). Five subjects (15%) were asymptomatic. Four out of the 11 subjects (36%) in group II had thrombotic events; they were all persistently aPL-positive and two of them had concomitant systemic lupus erythematosus. The rate of detection of LA-positivity was not significantly different between the two groups (76% vs 91%, p>0.05), whereas the percentage of patients positive for overall aCL was higher in group II than in group I (54% vs 42%, respectively; p<0.05). Specifically, aCL IgG and anti-β2GPI IgM subtypes were significantly more represented in group II than in group I (100% vs 62% and 75% vs 33%, respectively; p<0.05).
DISCUSSION: Our study shows that aPL-positive children have different features that should be taken into account in the classification of criteria for paediatric APS.
Paola Giordano; Riccardina Tesse; Giuseppe Lassandro; Deborah Fracchiolla; Prudenza Ranieri; Antonella Lotito; Domenico De Mattia; Giovanni Carlo Del Vecchio
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Publication Detail:
Type:  Journal Article     Date:  2011-12-21
Journal Detail:
Title:  Blood transfusion = Trasfusione del sangue     Volume:  10     ISSN:  1723-2007     ISO Abbreviation:  Blood Transfus     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-12-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101237479     Medline TA:  Blood Transfus     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  IM    
Department of Biomedicine of Developmental Age, University of Bari, Bari, Italy.
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MeSH Terms
Antibodies, Antiphospholipid / blood*
Antiphospholipid Syndrome / blood*,  epidemiology*
Child, Preschool
Partial Thromboplastin Time / methods
Prospective Studies
Retrospective Studies
Reg. No./Substance:
0/Antibodies, Antiphospholipid

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