Document Detail

Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi.
MedLine Citation:
PMID:  22370824     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Canine visceral leishmaniasis (CVL) is a zoonotic disease with different clinical manifestations. Parasitism often occurs in bone marrow, but changes have been observed in peripheral blood and serum biochemical parameters. The aim of this study was to evaluate the hematological and biochemical parameters in dogs naturally infected by Leishmania chagasi.
METHODS: Eighty-five adult dogs of both sexes and various weights and ages from the Zoonosis Control Center of Fortaleza (CCZ) were used, selected by immunofluorescence assay (IFA) and considered positive with IFA titers greater than 1:40 and by visualizing amastigotes of Leishmania chagasi in smears obtained by bone marrow aspiration. The dogs (n = 85) were grouped according to clinical signs: negative (CN = 7), subclinical (CS = 10), and clinical (CC = 68). Blood samples were collected for determination of hematological and biochemical serum values. The experimental protocol was approved by the CEUA/UECE.
RESULTS: The most frequent clinical signs were cachexia (77.9%), keratitis (61.8%), and lymphadenopathy (55.9%), and 86.8% of the animals showed more than one clinical sign characteristic of CVL. In CC were observed reductions in red blood cells (63%), hematocrit (72%), and hemoglobin (62%), as well as leukocytosis (33%), neutropenia (28%), thrombocytopenia (50%), uremia (45%), hyperproteinemia (53%, p<0.05), hypergammaglobulinemia (62%, p<0.01), and hypoalbuminemia (58%).
CONCLUSIONS: Animals with the clinical form of the disease demonstrate hematological and biochemical changes consistent with anemia, uremia, hyperproteinemia, and hyperglobulinemia, which present themselves as strong clinical markers of visceral leishmaniasis associated with the signs previously reported.
José Cláudio Carneiro de Freitas; Diana Célia Sousa Nunes-Pinheiro; Belarmino Eugênio Lopes Neto; Glauco Jonas Lemos Santos; Cyntia Rafaelle Amaral de Abreu; Roberta Rocha Braga; Rafael de Morais Campos; Ligene Fernandes de Oliveira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista da Sociedade Brasileira de Medicina Tropical     Volume:  45     ISSN:  1678-9849     ISO Abbreviation:  Rev. Soc. Bras. Med. Trop.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507456     Medline TA:  Rev Soc Bras Med Trop     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
Programa de Pós-Graduação em Ciências Veterinárias, Faculdade de Veterinária, Universidade Estadual do Ceará, Fortaleza, CE.
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