Document Detail


Clinical isolates and nasopharyngeal carriage of antibiotic-resistant Streptococcus pneumoniae in Hospital for Infectious Diseases, Sofia, Bulgaria, 1991-1993.
MedLine Citation:
PMID:  9156387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antimicrobial resistance of Streptococcus pneumoniae was surveyed in 1991-1993 at the Hospital for Infectious Diseases in Sofia, Bulgaria. Pneumococcal isolates were collected from routine clinical specimens and from nasopharyngeal secretions of inpatient carriers. The incidence of penicillin-resistant S. pneumoniae (PRSP) was 24.3% among clinical samples and nasopharyngeal carriage of PRSP was as high as 40% among children. Penicillin-resistant strains were more frequently resistant to non-beta-lactam antibiotics than were penicillin-sensitive strains. More than half of the PRSP strains were multiply resistant. On the basis of MIC values of ampicillin, it was established that ampicillin was not superior to penicillin. The MICs of five cephalosporins were found to increase in parallel with the MICs of penicillin G. Some of the pneumococcal strains that were highly penicillin-resistant were also resistant to cefotaxime/ceftriaxone (MIC = 1-4 micrograms/ml), but the number of strains was small. On the basis of MIC values of cefotaxime and ceftriaxone for strains from cerebrospinal fluid, both antibiotics may be suitable alternatives for treating meningitis due to strains with resistance to penicillin.
Authors:
L Setchanova
Related Documents :
2531117 - Effect of penicillin and spectinomycin given for urethritis and cervicitis with neisser...
3106607 - Efficacy of beta-lactamase-resistant penicillin and influence of penicillin tolerance i...
20670687 - Trends in antibiotic resistance in prevotella species from patients of the university h...
6300227 - Bordetella pertussis isolation in general practice: 1977-79 whooping cough epidemic in ...
9855237 - Slime production of staphylococcus epidermidis: increased bacterial adherence and accum...
17706197 - Deletion of the mto2 gene related to trna modification causes a failure in mitochondria...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microbial drug resistance (Larchmont, N.Y.)     Volume:  1     ISSN:  1076-6294     ISO Abbreviation:  Microb. Drug Resist.     Publication Date:  1995  
Date Detail:
Created Date:  1997-07-11     Completed Date:  1997-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508567     Medline TA:  Microb Drug Resist     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
Affiliation:
Hospital for Infectious Diseases, Department of Microbiology, Medical Faculty, HMS, Sofia, Bulgaria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bulgaria / epidemiology
Cross Infection
Drug Resistance, Microbial*
Humans
Pneumococcal Infections / epidemiology,  microbiology*
Streptococcus pneumoniae / drug effects,  genetics,  isolation & purification*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Novel penicillin-resistant clones of Streptococcus pneumoniae in the Czech Republic and in Slovakia.
Next Document:  In vitro development of resistance of Streptococcus pneumoniae to beta-lactam antibiotics.