| Clinical investigation of off-flap epi-LASIK for moderate to high myopia. | |
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MedLine Citation:
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PMID: 18515581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the clinical outcome of on-flap and off-flap epi-LASIK for moderate to high myopia. METHODS: This prospective, observer-masked, randomized study included 62 eyes of 31 patients with myopia who underwent off-flap epi-LASIK (epikeratome; Moria, Antony, France) in one eye (off-flap group) and on-flap epi-LASIK in the contralateral eye (on-flap group). Corneal ablation was performed with a commercially available laser (Mel-80; Carl Zeiss Meditec, Oberkochen, Germany). Patients were seen at 3, 5, and 12 days and 1 and 3 months after surgery. Clinical outcomes were compared between groups. RESULTS: No significant between-group differences in the mean preoperative spherical equivalent (-6.18 +/- 1.29 D vs. -6.47 +/- 1.70 D), the change in lines of best corrected visual acuity at 3 months after surgery, and postoperative pain were found. Compared with the on-flap group, outcomes of better uncorrected visual acuity at 3 and 5 days after surgery (P < 0.001), rapider reepithelialization (P < 0.001), and lower level of haze at 1 and 3 months after surgery (P = 0.04, 0.04) were found in the off-flap group. Three months after surgery, contrast sensitivity function (CSF), with and without glare, did not differ from before surgery in both groups (P > 0.05) except CSF at 18 cpd with glare increased significantly in the off-flap group 3 months after surgery (P = 0.04). Wavefront aberration increased significantly from baseline in both groups 3 months after surgery (P < 0.05). The on-flap group revealed greater but insignificant increasing amplitude in wavefront aberration compared with the off-flap group. CONCLUSIONS: In comparison with on-flap epi-LASIK, off-flap epi-LASIK offers comparable postoperative pain, a lower level of haze formation, a rapider visual recovery, and better visual quality. Further investigations of a larger number of subjects and longer follow-up periods are warranted. |
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Authors:
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Qin-Mei Wang; Ai-Cun Fu; Ye Yu; Chen-Chen Xu; Xiao-Xing Wang; Shi-Hao Chen; A-Yong Yu |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 49 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-02 Completed Date: 2008-07-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2390-4 Citation Subset: IM |
Affiliation:
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Affiliated Eye Hospital, Wenzhou Medical College, Zhejiang, Peoples Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contrast Sensitivity / physiology Cornea / surgery* Double-Blind Method Epithelium, Corneal / physiology Female Humans Keratomileusis, Laser In Situ / methods* Lasers, Excimer / therapeutic use* Male Myopia / surgery* Pain, Postoperative Prospective Studies Surgical Flaps* Tonometry, Ocular Treatment Outcome Visual Acuity / physiology Wound Healing / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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