Document Detail


Clinical investigation of malignant mesothelioma in Japan.
MedLine Citation:
PMID:  20213099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The asbestos-related problems caused much social concern; however, no large-scale study was conducted about clinical features of MM in Japan. Patients with MM who have a history of occupational asbestos exposure (AE) are provided worker's compensation in Japan. However, only about 10% of MM cases were actually claimed and compensated. So there is still controversy over the association between MM and AE. The aim of this study is to investigate the clinical features of MM. We also aimed to clarify the association between MM and occupational AE in Japan. METHODS: We examined the clinical features of MM cases. Clinical information was obtained including gender, age, site of origin, pathological subtype, radiological findings, and treatment outcome. To investigate the association between MM and AE, investigators interviewed all patients regarding work and residential history. RESULTS: Between January 2005 and December 2007, 105 cases (median age: 63 years, range 35-80, male/female: 88/17) were diagnosed with MM in the Rosai Hospital group and related facilities. Among them, 94(89.5%) cases originated in the pleura, 7(6.7%) in the peritoneum, 2(1.9%) in the pericardium, and 1(0.9%) in the tunica vaginalis testis. There were 69(65.7%) epithelioid, 19(18.1%) biphasic, 16(15.2%) sarcomatoid, and 1 unclassified pathological subtypes of MM. A favorable survival rate was indicated in the patient group of MPM that underwent surgery compared to others, though it was not statistically significant (P = 0.1743). The occupational AE was indicated in 89 cases (84.8%). Three patients had no history of occupational AE, but lived with someone who was in an occupation that handled asbestos. There were two patients in which AE was indicated in their life environment. Altogether, AE was indicated in 93(88.6%) patients. CONCLUSIONS: This study stresses the urgent need for physicians to acknowledge the association between MM and AE, and to inquire thoroughly regarding AE to the patients with MM.
Authors:
Nobukazu Fujimoto; Keisuke Aoe; Kenichi Gemba; Katsuya Kato; Koichi Yamazaki; Takumi Kishimoto
Related Documents :
11829239 - An evaluation of complications following dental extractions using either sterile or cle...
1813429 - One-appointment root canal treatment: incidence of postoperative pain using a modified ...
16212579 - Effect of the menstrual cycle on pain experience associated with periodontal therapy: r...
11306159 - Plaque, gingival health and post-operative sensitivity in titanium inlays and onlays: a...
11338309 - Combined mechanical and antibiotic periodontal therapy in a case of papillon-lefèvre s...
11128919 - Clinical evaluation of wound healing following multiple exposures to enamel matrix prot...
10402889 - A study of defaulters of treatment for diabetic retinopathy.
22382399 - Olfactory function following nasal surgery: a 1-year follow-up.
21889919 - Components anteversion in primary cementless tha using straight stem and hemispherical ...
Publication Detail:
Type:  Journal Article     Date:  2010-03-06
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  136     ISSN:  1432-1335     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2010-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1755-9     Citation Subset:  IM    
Affiliation:
Department of Respiratory Medicine, Okayama Rosai Hospital, 1-10-25 Chikkomidorimachi, Minamiku, Okayama 7028055, Japan. nfuji@okayamaH.rofuku.go.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Humans
Japan
Male
Mesothelioma / mortality,  pathology*
Middle Aged
Peritoneal Neoplasms / mortality,  pathology
Pleural Neoplasms / mortality,  pathology
Survival Analysis
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and e...
Next Document:  Expression and clinical significance of EGFL7 in malignant glioma.