Document Detail

Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  20609004     Owner:  NLM     Status:  In-Process    
AIM: Body mass index (BMI) is closely associated with mortality in chronic obstructive pulmonary disease (COPD). Systemic inflammation has been suggested as one of the mechanisms of malnutrition in COPD. This study investigated the relationships of clinical variables and inflammatory biomarkers with BMI in COPD in an aging population.
METHODS: Baseline levels of serum biomarkers were determined for 69 patients with stable male COPD. Multivariate logistic regression was used to evaluate associations between clinical variables, including emphysema scores, and biomarkers with BMI.
RESULTS: Twenty eight patients were categorized as low BMI (<20 kg/m2). BMI was inversely correlated with serum α1-antitrypsin (α1-AT) concentration and emphysema scores, and was positively correlated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). Multivariate logistic regression analysis showed that α1-AT was independently associated with BMI.
CONCLUSION: Low BMI was associated with the severity of emphysema and systemic inflammation reflected by elevated α1-AT level.
Yuji Higashimoto; Toshiyuki Yamagata; Noritsugu Honda; Ryuji Satoh; Hiroyuki Sano; Takashi Iwanaga; Takayuki Miyhara; Masato Muraki; Katsuyuki Tomita; Yuji Tohda; Kanji Fukuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Geriatrics & gerontology international     Volume:  11     ISSN:  1447-0594     ISO Abbreviation:  Geriatr Gerontol Int     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135738     Medline TA:  Geriatr Gerontol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  32-8     Citation Subset:  IM    
Copyright Information:
© 2010 Japan Geriatrics Society.
Department of Rehabilitation Medicine, Kinki University School of Medicine, Osaka, Japan.
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