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Clinical and inflammatory determinants of bronchial hyperresponsiveness in COPD.
MedLine Citation:
PMID:  22523354     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Bronchial hyperresponsiveness (BHR) is regarded as a hallmark of asthma, yet it is also present in a considerable number of COPD patients. Epidemiological studies have shown that BHR provides complementary information to FEV1 for development and progression of COPD. We hypothesized that the severity of BHR and its longitudinal changes associate with both clinical and airway inflammation measures in COPD. Our hypothesis was tested in 114 COPD patients (median age 62.9 years, packyears 45.9) participating in the GLUCOLD study, previously showing an improvement in BHR with fluticasone and fluticasone/salmeterol. At baseline, and 6 and 30 months after treatment, we investigated lung function, including body plethysmography, PC20 methacholine, sputum induction, and bronchial biopsies. By performing both cross-sectional and longitudinal analyses, we showed that BHR in COPD is predominantly associated with residual volume/total lung capacity, a measure of air trapping, and airway inflammation reflected by the number of neutrophils, macrophages, and lymphocytes in sputum and bronchial biopsies. Our findings indicate that BHR is an independent trait in COPD and provides important information on phenotype heterogeneity and disease activity.
Authors:
M van den Berge; J M Vonk; M Gosman; T S Lapperre; J B Snoeck-Stroband; P J Sterk; L I Z Kunz; P S Hiemstra; W Timens; N H T Ten Hacken; H A M Kerstjens; D S Postma
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
PO Box 30.001 NL-9700-RB, University Medical Center Groningen, University of Groningen, the Netherlands.
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