Document Detail

Clinical indicators for pulmonary arterial hypertension in thalassemia.
MedLine Citation:
PMID:  22379736     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To explore clinical indicators for pulmonary arterial hypertension (PAH) in thalassemia (Thal).
MATERIAL AND METHOD: A study was conducted in thalassemia patients at Chiang Rai Hospital, Chiang Rai, Thailand. Pulmonary artery systolic pressure (PASP) was determined by doppler echocardiography and PAH was defined as PASP > 35 mmHg. Patient characteristics were extracted from medical records. Characteristics of patients with and without PAH were compared. Risk indicators were explored with logistic regression analysis.
RESULTS: Two hundred twenty four patients were included, 144 E/beta-Thal, 37 homozygous beta-Thal and 43 Hb H disease. There were 65 patients (29.0%) with PAH, 53 (81.5%) with E/beta-Thal, 8 (12.3%) with homozygous beta-Thal and 4 (6.2%) with Hb H disease. In a multivariable analysis, features significantly associated with PAH were E/beta-Thal (OR = 1.98, 95% CI; 1.29-3.01) and post splenectomy status (OR = 2.36, 95% CI; 1.17-4.73).
CONCLUSION: Significant indicators for PAH in thalassemia were E/beta-Thal and post splenectomy status.
Nonlawan Chueamuangphan; Wattana Wongtheptien; Weerasak Nawarawong; Apichard Sukornthasarn; Suporn Chuncharunee; Chamaiporn Tawichasri; Jayanton Patumanond
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  95     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-03-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  IM    
Department of Medicine, Chiang Rai Hospital, Chiang Rai, Thailand.
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