Document Detail

Clinical importance of human herpes virus-8 and human immunodeficiency virus infection in primary effusion lymphoma.
MedLine Citation:
PMID:  23278643     Owner:  NLM     Status:  Publisher    
Abstract Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that usually develops in immunosuppressed patients infected with human herpes virus 8 (HHV8) in conjunction with human immunodeficiency virus (HIV) infection. However, there are several reports of HHV-8-related HIV-negative cases and HHV8-unrelated HIV-negative cases, mainly in immunodeficient and elderly patients. Here, we report 1 case of HHV8-related HIV-negative PEL with gastric cancer (case 1), and 1 case of HHV8-unrelated HIV-negative effusion-based lymphoma (case 2), both in elderly men. A 73-year-old man and a 79-year-old man were admitted because of lymphomatous effusions, and no mass was detectable in both cases. They were diagnosed as having malignant effusion lymphoma on the basis of cytological findings indicating atypical lymphoid cells and the expression of CD20 and CD79a. To detect evidence of HHV8 infection in neoplastic cells, immunocytochemical staining for ORF73/latent nuclear antigen-1 (LNA-1) was performed. The results revealed that case 1 ORF73-positive, and case 2 was ORF73-negative. Rituximab-based chemotherapy (R-THPCOP) was administrated to both patients and complete remission was achieved in both. Compared to most HIV-positive PEL cases, these 2 cases showed good response to chemotherapy. In PEL cases, we should focus on HHV-8 infection and HIV status for determining prognosis.
Takahiro Kumode; Yasuyo Ohyama; Masaya Kawauchi; Terufumi Yamaguchi; Jun-Ichi Miyatake; Yoshihiko Hoshida; Yoichi Tatsumi; Itaru Matsumura; Yasuhiro Maeda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-2
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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