Document Detail

Clinical implications of understanding radiographic findings in relation to clinical outcomes in rheumatoid arthritis.
MedLine Citation:
PMID:  19509325     Owner:  NLM     Status:  MEDLINE    
The clinical progression of rheumatoid arthritis (RA) and longterm response to therapy is generally assessed by quantifying changes in joint space narrowing and erosions visible on serial plain radiographs. In patients treated with classic disease modifying antirheumatic drugs, the joint damage seen on radiographic images is usually directly associated with longterm functional disability. However, this relationship is not as clearly defined in patients treated with biologic agents. The apparent dissociation between clinical and radiologic outcomes in patients with RA who are treated with biologic therapies needs to be taken into consideration when evaluating the efficacy of treatment.
Edward C Keystone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of rheumatology. Supplement     Volume:  82     ISSN:  0380-0903     ISO Abbreviation:  J Rheumatol Suppl     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-10     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806058     Medline TA:  J Rheumatol Suppl     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, The Joseph and Wolf Lebovic Building, 60 Murray Street, 2nd Floor, Room 2-006, Toronto, Ontario M5T 3L9.
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MeSH Terms
Antirheumatic Agents / therapeutic use*
Arthritis, Rheumatoid / drug therapy*,  radiography*
Biological Products / therapeutic use
Clinical Competence
Disability Evaluation
Drug Monitoring
Joints / pathology*
Methotrexate / therapeutic use
Predictive Value of Tests
Severity of Illness Index
Synovitis / drug therapy,  radiography
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 0/Biological Products; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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