| Clinical implications of a possible role of vitamin D in multiple sclerosis. | |
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MedLine Citation:
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PMID: 19399382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypovitaminosis D is currently one of the most studied environmental risk factors for multiple sclerosis (MS) and is potentially the most promising in terms of new clinical implications. These practical consequences, which could be applied to MS patients without further delay, constitute the main purpose of this review. Vitamin D is involved in a number of important general actions, which were not even suspected until quite recently. In particular, this vitamin could play an immunomodulatory role in the central nervous system. Many and varied arguments support a significant role for vitamin D in MS. In animal studies, vitamin D prevents and improves experimental autoimmune encephalomyelitis. Epidemiologically, latitude, past exposure to sun and the serum level of vitamin D influence the risk of MS, with, furthermore, significant links existing between these different factors. Clinically, most MS patients have low serum levels of vitamin D and are in a state of insufficiency or even deficiency compared to the international norm, which has been established on a metabolic basis. Large therapeutic trials using vitamin D are still lacking but the first results of phase I/II studies are promising. In the meantime, while awaiting the results of future therapeutic trials, it can no longer be ignored that many MS patients have a lack of vitamin D, which could be detected by a serum titration and corrected using an appropriate vitamin D supplementation in order to restore their serum level to within the normal range. From a purely medical point of view, vitamin D supplementation appears in this light to be unavoidable in order to improve the general state of these patients. Furthermore, it cannot currently be ruled out that this supplementation could also be neurologically beneficial. |
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Authors:
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Charles Pierrot-Deseilligny |
Publication Detail:
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Type: Journal Article; Review Date: 2009-04-28 |
Journal Detail:
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Title: Journal of neurology Volume: 256 ISSN: 1432-1459 ISO Abbreviation: J. Neurol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-27 Completed Date: 2009-11-02 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 1468-79 Citation Subset: IM |
Affiliation:
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Service de Neurologie 1, Hôpital de la Salpêtrière, Assistance Publique, Hôpitaux de Paris, 75657 Paris Cedex 13, France. cp.deseilligny@psl.aphp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Geography Humans Multiple Sclerosis / epidemiology, metabolism*, therapy Prevalence Sunlight Vitamin D / administration & dosage, blood, metabolism* Vitamin D Deficiency / drug therapy, epidemiology Vitamins / administration & dosage, blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Vitamins; 1406-16-2/Vitamin D |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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