Document Detail

Clinical implications of patent foramen ovale in migraine with aura.
MedLine Citation:
PMID:  19331783     Owner:  NLM     Status:  MEDLINE    
The high incidence of patent foramen ovale (PFO) in migraine with aura (MWA) is well known. In this study we evaluated the relationship between PFO and aura features, and the relative impact of this association on stroke risk. We recruited patients with a diagnosis of MWA. PFO was assessed by contrast transcranial Doppler and confirmed by transoesophageal echocardiography. The 65 patients enrolled were divided into two groups on the basis of the clinical features of their aura: typical in 63.1% (Group 1) and atypical in 36.9% (Group 2). A statistically significant difference was found in PFO prevalence between the two groups (46.3% in Group 1 and 79.2% in Group 2; p=0.009). We did not observe any statistical difference between the two groups in the prevalence of classic stroke risk factors or in the profile of the thrombophilic markers. Our results underline the need to look for PFO particularly in subjects with atypical features of aura, but the underlying pathophysiology of the association is not clear.
Pasquale Marchione; Natascia Ghiotto; Grazia Sances; Elena Guaschino; D Bosone; G Nappi; Patrizia Giacomini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Functional neurology     Volume:  23     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    2008 Oct-Dec
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  201-5     Citation Subset:  IM    
Neurovascular Unit, Department of Neurology and Otorhinolaringology, University La Sapienza, Rome, Italy.
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MeSH Terms
Echocardiography / methods
Echocardiography, Transesophageal / methods
Foramen Ovale, Patent / complications*,  diagnosis*,  epidemiology,  ultrasonography
Middle Aged
Migraine with Aura / complications*,  epidemiology,  ultrasonography
Severity of Illness Index

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