Document Detail

Clinical implications of new findings in HIV basic research.
MedLine Citation:
PMID:  20657756     Owner:  NLM     Status:  Publisher    
HIV has been studied extensively over the past 25 years. Insights into the different stages of the virus' replication cycle and its interaction with host-cell proteins have led to the development of an armamentarium of effective antiretroviral medications. These antiviral drugs have dramatically changed the prognosis for HIV-infected subjects from an inevitable march towards death to a chronic disease with a potentially normal lifespan. Even with these successes, there is a continuing need to provide new drugs, especially those effective against drug-resistant viruses, to devise optimal strategies to prevent adverse events from either immunosuppression or the antiretroviral medications, and to develop treatments aimed at eliminating virus replication in the absence of antiviral drugs. In this review, how these important issues are being addressed will be highlighted, emphasizing clinical implications from some recent basic science studies and demonstrating how they could change the face of HIV therapeutics over the next 5-10 years.
Manish Sagar
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Publication Detail:
Journal Detail:
Title:  HIV therapy     Volume:  3     ISSN:  1758-4329     ISO Abbreviation:  -     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2010-7-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500287     Medline TA:  HIV Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  351-360     Citation Subset:  -    
Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Room 447, Cambridge, MA 02139, USA, Tel.: +1 617 768 8372; ;
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Grant Support
R01 AI077473-02//NIAID NIH HHS

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