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Clinical implications of clotting screens.
MedLine Citation:
PMID:  24636194     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Coagulation screens are performed routinely in every hospital with the notion that an abnormal result will pick up low levels of coagulation factors and thus aid in determining patients' bleeding risk.
METHODS: We analysed all the clotting factor assays performed for abnormal clotting screen in a tertiary hospital over a 1-year period.
RESULTS: Isolated prolongation of prothrombin time (PT) is extremely rarely clinically significant, and there is no correlation with degree of prolongation and factor VII deficiency. One-third cases of isolated prolonged activated partial thromboplastin time (APTT) were clinically insignificant, while in the rest, a factor deficiency which may be deemed as a potential risk for bleeding was noted. Prolonged PT and APTT in combination were noted in 38 cases, but in 29 of these patients all the measured clotting factors and fibrinogen were in the normal range.
CONCLUSION: Abnormal clotting screens may not always be associated with clinically significant decrease in coagulation factor.
Authors:
S E Thorell; M J Nash; J Thachil
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-17
Journal Detail:
Title:  International journal of laboratory hematology     Volume:  -     ISSN:  1751-553X     ISO Abbreviation:  Int J Lab Hematol     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300213     Medline TA:  Int J Lab Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 John Wiley & Sons Ltd.
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