| Clinical implication of plasma natriuretic peptides in children with ventricular septal defect. | |
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MedLine Citation:
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PMID: 12828576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is little information available concerning plasma concentrations of B-type natriuretic peptide (BNP) in children with a ventricular septal defect. The aim of the present study was to determine hemodynamic factors that control plasma concentrations of BNP and the clinical implications of BNP compared with atrial natriuretic peptide (ANP) in children with ventricular septal defect. METHODS: Fifty-nine patients with ventricular septal defect (28 boys and 31 girls) without pulmonary vascular disease were enrolled. The patients' ages ranged from 3 months to 13 years (mean 3.1 years). Plasma BNP and ANP were determined by immunoradiometric assay. Hemodynamic variables derived from cardiac catheterization were analyzed in terms of correlation with BNP and ANP. RESULTS: It was found that plasma BNP significantly positively correlated with ANP (ANP = 2.1 x BNP + 25 pg/mL; r = 0.81, P < 0.0001) and BNP never exceeded ANP in the present patient series. Plasma BNP as well as ANP significantly positively correlated with pulmonary to systemic flow ratio (r = 0.65 and r = 0.59, respectively) and mean pulmonary artery pressure (r = 0.72 and r = 0.68, respectively). In addition, plasma BNP of > or =20 pg/mL and ANP of > or =50 pg/mL identified children with mean pulmonary artery pressure of > or =20 mmHg with a sensitivity of 82% and 97%, respectively, and a specificity of 89% and 84%, respectively. CONCLUSION: Plasma BNP and ANP reflect pressure and volume loads to the pulmonary artery and right ventricle and may help to identify children with ventricular septal defect complicated by pulmonary hypertension that demands early intervention. |
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Authors:
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Kenji Suda; Masahiko Matsumura; Masahiko Matsumoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatrics international : official journal of the Japan Pediatric Society Volume: 45 ISSN: 1328-8067 ISO Abbreviation: Pediatr Int Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-27 Completed Date: 2003-10-14 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 100886002 Medline TA: Pediatr Int Country: Australia |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Affiliation:
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Division of Pediatric Cardiology, Department of Pediatrics, Tenri Hospital, Tenri City, Japan. kensuda@tenriyorozu-hp.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Atrial Natriuretic Factor / blood* Blood Pressure Child Child, Preschool Female Heart Failure / etiology Heart Septal Defects, Ventricular / blood*, complications, physiopathology Hemodynamics* Humans Infant Male Natriuretic Peptide, Brain Pulmonary Circulation Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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