Document Detail

Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: an update.
MedLine Citation:
PMID:  20690087     Owner:  NLM     Status:  MEDLINE    
Gastrointestinal (GI) bleeding due to colonic angiodysplasias can be associated with calcifying aortic stenosis (AS). GI angiodysplasias and AS are defined as chronic degenerative disorders, and the prevalence of both diseases increases with age. Moreover, degenerative AS is associated with increased destruction of high molecular weight multimers of von Willebrand factor which can promote bleeding from intestinal angiodysplasias. The coincidence of gastrointestinal bleeding angiodysplasias and AS has been known for many years as Heyde's syndrome. Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. In this study, we tried to collect as well as systemized data about the etiopathogenesis of AS coagulation abnormalities and diagnostic, clinical and therapeutic implications of AS-patient with GI angiodysplasias.
Wojciech Gola; Małgorzata Lelonek
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-06     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  330-4     Citation Subset:  IM    
Department of Cardiology, Sterling Memorial University Hospital, Medical University of Łódź, Sterlinga 1/3, Łódź, Poland.
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MeSH Terms
Angiodysplasia / blood,  complications*,  epidemiology,  surgery
Aortic Valve Stenosis / blood,  complications*,  epidemiology,  surgery
Blood Coagulation*
Endoscopy, Gastrointestinal
Gastrointestinal Hemorrhage / blood,  epidemiology,  etiology*,  prevention & control
Heart Valve Prosthesis Implantation
Intestinal Diseases / blood,  complications*,  epidemiology,  surgery
von Willebrand Diseases / blood,  complications*,  epidemiology
von Willebrand Factor / metabolism
Reg. No./Substance:
0/von Willebrand Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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