| Clinical impact of whole body FDG-PET for recurrent biliary cancer: a multicenter study. | |
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MedLine Citation:
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PMID: 19756919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the clinical usefulness of positron emission tomography (PET) using (18)F-fluorodeoxyglucose (FDG) in patients with follow-up or suspected recurrent biliary cancer in a multicenter study. METHODS: We performed a retrospective review of 50 patients who underwent FDG-PET (either integrated PET/CT or manual fusion of dedicated PET and CT) scans for post-treatment surveillance of biliary cancer. Recurrence was suspected in 40 of these patients on the basis of tumor marker levels, and/or findings of conventional imaging (group A). Clinical findings in the remaining 10 patients showed them to be disease-free (group B). The diagnostic performance and clinical impact of PET were analyzed. RESULTS: Recurrence was confirmed in 28 out of the 40 patients in group A, and 1 of the 10 patients in group B. Patient-based analysis showed that the sensitivity, specificity, and accuracy of PET for detecting recurrence were 86% (25/29), 91% (19/21), and 88% (44/50), respectively. The one patient with recurrence in group B was correctly interpreted by PET. Positive test likelihood ratio and negative test likelihood ratio were increased from 1.69 to 9.05, and 0.08 to 0.32, respectively, after PET study. The findings of PET resulted in a change of management for 10 out of the 50 patients (20%) by initiating an unplanned treatment strategy (n = 7), by obviating the need for planned diagnostic procedures (n = 2), or by changing the treatment plan (n = 1). CONCLUSION: FDG-PET/CT or PET with CT yielded helpful information in patients with suspected recurrent biliary cancer. |
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Authors:
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Kazuhiro Kitajima; Koji Murakami; Kakuko Kanegae; Nagara Tamaki; Tomohiro Kaneta; Hiroshi Fukuda; Kotaro Nakajima; Hirofumi Fujii; Ukihide Tateishi; Kazuo Kubota; Tsuyoshi Suga; Yuji Nakamoto |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-09-12 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 23 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 709-15 Citation Subset: IM |
Affiliation:
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Department of Radiology, Dokkyo Medical University School of Medicine, Shimotuka-gun, Tochigi, 321-0293, Japan. kazu10041976@yahoo.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biliary Tract Neoplasms / radiography, radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Positron-Emission Tomography* Recurrence Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed Whole Body Imaging* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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