Document Detail


Clinical impact of thymidine phosphorylase expression in gastric cancer.
MedLine Citation:
PMID:  12684624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thymidine phosphorylase (dThdPase) is an enzyme that is involved in pyrimidine nucleoside metabolism and DNA synthesis and converts 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil (5-FU). The aim of this study was to elucidate the relationship between dThdPase expression and biological malignancy, prognosis, and sensitivity to postoperative chemotherapy, using immunohistochemical staining. We studied 148 patients with gastric cancer who underwent surgery at Department of Surgery II in Oita Medical University between 1990 and 1999. Immunohistochemical expression of dThdPase was correlated to clinicopathological factors and postoperative survival. Tumor tissue was dThdPase-positive in 112 patients. The results suggested a relationship between the degree of histological differentiation and dThdPase expression (p=0.0697). Examination of dThdPase expression based on the site of the tumor revealed that the groups with upper or lower gastric cancer included a significantly greater number of dThdPase-positive patients (p=0.0011). Analysis of the patients as a whole showed no significant difference between the survival. In the chemotherapy group, the dThdPase-positive patients tended to have a more favorable prognosis than the dThdPase-negative patients (p=0.0578). The results suggest that postoperative adjuvant chemotherapy that makes use of FU metabolic pathways may improve prognosis in patients with dThdPase-positive gastric cancer.
Authors:
Tsuyoshi Noguchi; Shozo Fujiwara; Shinsuke Takeno; Shinya Kai; Akari Mizuta; Yuko Nagao; Yuzo Uchida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology reports     Volume:  10     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-04-09     Completed Date:  2003-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  561-6     Citation Subset:  IM    
Affiliation:
Department of Oncological Science (Surgery II), Oita Medical University, Isaigaoka 1-1, Hasama-machi, Oita 879-5593, Japan. surg2@oita-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cell Differentiation
Female
Humans
Immunoenzyme Techniques
Lymph Nodes / pathology
Male
Middle Aged
Neoplasm Invasiveness / pathology
Neoplasm Staging
Prognosis
Stomach Neoplasms / enzymology*,  pathology,  surgery
Survival Rate
Thymidine Phosphorylase / metabolism*
Chemical
Reg. No./Substance:
EC 2.4.2.4/Thymidine Phosphorylase

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