| Clinical impact of, and prognostic stratification by, F-18 FDG PET/CT in head and neck mucosal squamous cell carcinoma. | |
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MedLine Citation:
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PMID: 17563906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to determine prospectively the incremental value of positron emission tomography/computed tomography (PET/CT) over conventional assessment (clinical examination and CT/MRI imaging). METHODS: All patients undergoing (18)F-fluorodeoxyglucose (FDG)-PET/CT for primary head and neck mucosal squamous cell carcinoma between January 2002 and December 2003 (inclusive) were included in this study provided they had undergone contemporaneous conventional assessment of the head and neck region and had 12 months minimum follow-up. RESULTS: Seventy-six patients underwent 100 PET/CT scans. The majority of patients (74%) were treated with definitive (chemo)radiotherapy. Median follow-up time was 28 months. PET/CT led to a TNM classification alteration in 34% (12/35), a change in radiotherapy planning technique and/or dose in 29% (10/35), and altered treatment response assessment in 43% (13/30). A complete metabolic response was predictive of overall survival (p = .037). CONCLUSION: Our results support incorporation of PET/CT into the management paradigm of head and neck mucosal squamous cell carcinoma. |
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Authors:
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Caroline A Connell; June Corry; Alvin D Milner; Annette Hogg; Rodney J Hicks; Danny Rischin; Lester J Peters |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Head & neck Volume: 29 ISSN: 1043-3074 ISO Abbreviation: Head Neck Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-16 Completed Date: 2008-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 986-95 Citation Subset: IM |
Affiliation:
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Division of Radiation Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Australia. carolineconnell@yahoo.com.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / radiography*, radionuclide imaging*, therapy Female Fluorodeoxyglucose F18 / diagnostic use Follow-Up Studies Head and Neck Neoplasms / radiography*, radionuclide imaging*, therapy Humans Male Middle Aged Mucous Membrane Neoplasm Staging Positron-Emission Tomography* Predictive Value of Tests Radiopharmaceuticals / diagnostic use Tomography, X-Ray Computed* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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