| Clinical impact of identifying lactose maldigestion or fructose malabsorption in irritable bowel syndrome or other conditions. | |
| | |
MedLine Citation:
|
PMID: 19738525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The role of carbohydrate maldigestion or malabsorption remains unclear in patients with irritable bowel syndrome (IBS). The purpose of this study was to examine the impact of identifying lactose maldigestion (LM) and fructose malabsorption (FM) on patients with and without IBS. METHODS: Patients who received lactose and fructose challenge testing formed the study group. Carbohydrate challenge testing was performed with 50 g lactose and 25 g fructose. Breath samples were collected and analyzed for hydrogen, methane, and CO2 (for correction) using a MicroLyzer Model SC (QuinTron Instrument Company, Milwaukee, WI). Questionnaires were used to assess Rome III IBS criteria, compliance with carbohydrate dietary modifications, and changes in symptoms. RESULTS: One hundred and twenty-one of the 181 (67%) study subjects were able to be contacted 8 months to 4 years after carbohydrate testing. LM (21) and FM (2) were seen in 33% of the 66 IBS subjects. LM (12) and FM (9) were seen in 33% of the 55 subjects without IBS. Seventy-seven percent of IBS and 72% of those without IBS reported compliance with dietary advice. Of the subjects who reported compliance, 47% of IBS and 77% of those without IBS reported that, after identifying LM or FM, their symptoms resolved or improved. CONCLUSIONS: Carbohydrate maldigestion has a similar incidence in patients with and without IBS and both populations have similar compliance with therapeutic diets. However, patients without IBS are more likely to have improvement in symptoms when dietary changes are instituted when compared to IBS patients. |
| | |
Authors:
|
Meredith Corlew-Roath; Jack A Di Palma |
Related Documents
:
|
12608175 - Gluten and the small intestine in rheumatoid arthritis. 19424595 - Ghrelin in patients with irritable bowel syndrome. 6701455 - Conventional malabsorption tests: do they detect the adult patient with villous atrophy? 17119385 - Predictive value of the card15 variant 1007fs for the diagnosis of intestinal stenoses ... 6688035 - Studies on lymphomata. iii. lymphomata, granulomata and tuberculosis. 6862845 - Value of spirometric investigations in amyotrophic lateral sclerosis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Southern medical journal Volume: 102 ISSN: 1541-8243 ISO Abbreviation: South. Med. J. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-11-02 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
|
Languages: eng Pagination: 1010-2 Citation Subset: AIM; IM |
Affiliation:
|
Division of Gastroenterology, University of South Alabama College of Medicine, Mobile, Alabama 36693, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Breath Tests Female Follow-Up Studies Fructose / diagnostic use, pharmacokinetics* Humans Intestinal Absorption / physiology* Irritable Bowel Syndrome / diet therapy, physiopathology* Lactose / diagnostic use Lactose Intolerance / physiopathology* Male Patient Compliance Sweetening Agents / diagnostic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Sweetening Agents; 30237-26-4/Fructose; 63-42-3/Lactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Celiac disease associated with dilated cardiomyopathy.
Next Document: Vitamin deficiency after gastric bypass surgery: a review.