Document Detail

Clinical impact of fluorodeoxyglucose-positron emission tomography scan/computed tomography in comparison with computed tomography on the detection of colorectal cancer recurrence.
MedLine Citation:
PMID:  21304319     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND AIMS: Early detection is an essential prognostic factor in colorectal cancer (CRC) recurrence. Our aim was to evaluate diagnostic performances of F-fluorodeoxyglucose-positron emission tomography (F-FDG-PET)/computed tomography (CT) as compared with CT in the detection of CRC recurrence.
METHODS: Data of patients with suspected CRC recurrence and in whom both FDG-PET/CT and CT were performed were analyzed. All detected lesions were characterized according to their number, size, and localization. Positive histological or radiological follow-up was considered as the 'gold standard'. Diagnostic performances of FDG-PET/CT and CT were calculated by lesion, globally and with respect to the site of recurrence.
RESULTS: One hundred and seventy-six true-positive lesions were identified in 71 patients. CT scan was positive in 58 (82%) patients and FDG-PET/CT in 70 (98%) patients. In per lesion analysis, the global accuracy of FDG-PET/CT in detection of lesions was of 88% (sensitivity=95%, specificity=54%), which was higher than that of CT (53%, sensitivity=55%, specificity=43%), particularly in case of lymph nodes metastases (100 vs. 35%) and locoregional lesions (100 vs. 39%) (P<0.0001). FDG-PET/CT modified the clinical management in 31 patients.
CONCLUSIONS: FDG-PET/CT is more sensitive than CT for diagnosis of CRC recurrence and can modify the management in 40% of patients.
Céline Deleau; Bruno Buecher; Caroline Rousseau; Françoise Kraeber-Bodéré; Mathurin Flamant; Stanislas Bruley des Varannes; Eric Frampas; Jean-Paul Galmiche; Tamara Matysiak-Budnik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  23     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  IM    
aInstitut des Maladies de l'Appareil Digestif-CIC INSERM 04 et Service d'Hépato-Gastroentérologie bService de Radiologie, CHU de Nantes cService de Médecine Nucléaire, CHU/CLCC - INSERM U892 CRCNA, Nantes Saint-Herblain, France.
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