| Clinical impact and drivers of non-adherence to maintenance medication for inflammatory bowel disease. | |
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MedLine Citation:
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PMID: 21548837 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Inflammatory bowel diseases (IBDs) require maintenance medication to sustain remission and as a prophylaxis against the development of colorectal dysplasia. Non-adherence can compromise the effectiveness of treatment plans. Areas covered: Depending on study cohort and country, 7 - 72% of IBD patients do not adhere to maintenance medication plans. Non-adherence is associated with an increased number of flares and increased healthcare utilization costs. Several factors, such as experiencing side effects and demographic, socioeconomic, disease-specific and psychological variables have been associated with non-adherence in IBD. Data on demographic, socioeconomic and disease-specific variables are inconsistent, while data on psychological distress, patients' beliefs about medication and discordant doctor-patient relationships are more consistently associated with non-adherence. There has been a change towards investigation of modifiable factors for non-adherence in the recent literature. Expert opinion: Currently, there is no simple and effective intervention to improve adherence to IBD maintenance medication. Anxiety, beliefs about medicines and the doctor-patient relationship are promising targets for interventions, but require further study. |
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Authors:
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Christian P Selinger; Andrew Robinson; Rupert W Leong |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-9 |
Journal Detail:
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Title: Expert opinion on drug safety Volume: - ISSN: 1744-764X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101163027 Medline TA: Expert Opin Drug Saf Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Gastroenterology , Salford Royal Hospital, Stott Lane, Salford, M6 8HD , UK Christian.selinger@web.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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