| Clinical impact of (11)C-methionine PET on expected management of patients with brain neoplasm. | |
| | |
MedLine Citation:
|
PMID: 19915838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: We retrospectively examined the clinical efficacy of (11)C-methionine positron emission tomography ((11)C-MET PET) in patients with brain neoplasm, especially whether the (11)C-MET PET changed the clinical management and whether the change was beneficial or detrimental. METHODS: This study reviewed 89 (11)C-MET PET scans for 80 patients (20 scans for initial diagnosis of brain tumor and 69 scans for differentiating tumor recurrence from radiation necrosis). Final diagnosis and the effect on the intended management were obtained from the questionnaire to the referring physicians or directly from the medical records. The diagnostic sensitivity, specificity, and accuracy for the (11)C-MET PET were evaluated. Regarding the management impact, the rate of scans that caused changes in intended management was also evaluated. Moreover, the occurrence of scans having detrimental diagnostic impact (DDI) and beneficial diagnostic impact (BDI) were evaluated. RESULTS: Sensitivity, specificity, and accuracy of (11)C-MET PET was 87.8, 80.0, and 85.9%. The intended management was changed in 50.0% of the scans. DDI and BDI were observed in 4.3 and 36.2% of the total relevant scans, respectively. CONCLUSION: (11)C-MET PET can provide useful information in initial diagnosis and differentiating tumor recurrence from radiation necrosis. The intended management was changed in half of the scans. Since a few cases did not receive the requisite treatment due to false-negative results of (11)C-MET PET, management decision should be made carefully, especially in the case of a negative scan. |
| | |
Authors:
|
Tomohiko Yamane; Setsu Sakamoto; Michio Senda |
Related Documents
:
|
10418088 - Varicocele--a historical perspective. 10129448 - Is your organization ready for change? 8850768 - Midwifery in new zealand: responding to changing times. 23052648 - Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from kdigo. 11246918 - Introducing t-shaped managers. knowledge management's next generation. 19208018 - Awareness of management of dental trauma among medical professionals in pondicherry, in... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article Date: 2009-11-14 |
Journal Detail:
|
Title: European journal of nuclear medicine and molecular imaging Volume: 37 ISSN: 1619-7089 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-25 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
|
Languages: eng Pagination: 685-90 Citation Subset: IM |
Affiliation:
|
Division of Molecular imaging, Institution of Biomedical Research and Innovation, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan. yamane@fbri.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Brain / radiation effects, radionuclide imaging Brain Neoplasms / radionuclide imaging*, radiotherapy, secondary, therapy Carbon Radioisotopes / analysis, diagnostic use* Carcinoma / radionuclide imaging, secondary Child Decision Making Diagnosis, Differential False Negative Reactions Female Glioma / radionuclide imaging*, therapy Humans Lymphoma, Non-Hodgkin / radionuclide imaging Male Methionine / analysis, diagnostic use* Middle Aged Neoplasm Recurrence, Local / radionuclide imaging Patient Care Planning* Positron-Emission Tomography* Radiation Injuries / radionuclide imaging Radiopharmaceuticals / analysis, diagnostic use* Radiotherapy / adverse effects Sensitivity and Specificity Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Radioisotopes; 0/Radiopharmaceuticals; 63-68-3/Methionine |
| Comments/Corrections | |
Comment In:
|
Eur J Nucl Med Mol Imaging. 2010 Apr;37(4):683-4
[PMID:
20107786
]
|
Erratum In:
|
Eur J Nucl Med Mol Imaging. 2010 Apr;37(4):831 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Radiobiological effects of hypoxia-dependent uptake of 64Cu-ATSM: enhanced DNA damage and cytotoxici...
Next Document: FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0.