| Clinical and immunological features in IgM deficiency. | |
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MedLine Citation:
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PMID: 19494527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: IgM deficiency is a dysgammaglobulinemia characterized by isolated low levels of serum IgM. Patients with IgM deficiency may exhibit various clinical manifestations. However, IgM deficiency still remains to be explored with regard to diagnosis and treatment. METHODS: Through a retrospective chart review, we investigated the clinical and immunological features of 15 symptomatic adult IgM-deficient patients who were referred to our immunology clinics over a 4-year period. RESULTS: The patients were comprised of 6 males and 9 females, with a mean age of 57.2 years. On initial evaluation, 12 patients (80%) presented with susceptibility to infections, 5 (33%) had atopic manifestations such as asthma and allergic rhinitis, 3 (20%) had both infections and atopy, 4 patients (28%) had fibromyalgia-like symptoms, 3 (20%) had autoimmune manifestations, and 1 patient had lymphoma. The mean serum IgM level was 27.4 mg/dl (range 14-39). Impaired specific antibody response to pneumococcal antigens in 5 out of 11 studied patients (45%) appeared to be a notable association. Subtle abnormalities in IgG subclasses, lymphocyte subsets and in vitro proliferative lymphocyte responses were observed. Five patients who were treated with intravenous immunoglobulin responded very well. CONCLUSION: We propose that a thorough immunological evaluation including specific antibody responses be undertaken in patients with IgM deficiency. IgM-deficient patients who present with recurrent/severe infections may benefit from immunoglobulin treatment particularly in the presence of impaired pneumococcal antibody responses. |
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Authors:
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Leman Yel; Srinivasan Ramanuja; Sudhir Gupta |
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Publication Detail:
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Type: Journal Article Date: 2009-06-04 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 150 ISSN: 1423-0097 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-15 Completed Date: 2009-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 291-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA. lyel@uci.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, Bacterial / immunology Diagnosis, Differential Dysgammaglobulinemia / blood, diagnosis*, immunology, physiopathology, therapy Female Humans Hypersensitivity, Immediate / blood, diagnosis*, immunology, physiopathology, therapy Immunity, Humoral Immunoglobulin M / blood, deficiency Immunoglobulins, Intravenous / therapeutic use Male Middle Aged Pneumococcal Infections / blood, diagnosis*, immunology, physiopathology, therapy Recurrence Retrospective Studies Streptococcus pneumoniae / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Bacterial; 0/Immunoglobulin M; 0/Immunoglobulins, Intravenous |
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