Document Detail

Clinical and immunological features in IgM deficiency.
MedLine Citation:
PMID:  19494527     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: IgM deficiency is a dysgammaglobulinemia characterized by isolated low levels of serum IgM. Patients with IgM deficiency may exhibit various clinical manifestations. However, IgM deficiency still remains to be explored with regard to diagnosis and treatment. METHODS: Through a retrospective chart review, we investigated the clinical and immunological features of 15 symptomatic adult IgM-deficient patients who were referred to our immunology clinics over a 4-year period. RESULTS: The patients were comprised of 6 males and 9 females, with a mean age of 57.2 years. On initial evaluation, 12 patients (80%) presented with susceptibility to infections, 5 (33%) had atopic manifestations such as asthma and allergic rhinitis, 3 (20%) had both infections and atopy, 4 patients (28%) had fibromyalgia-like symptoms, 3 (20%) had autoimmune manifestations, and 1 patient had lymphoma. The mean serum IgM level was 27.4 mg/dl (range 14-39). Impaired specific antibody response to pneumococcal antigens in 5 out of 11 studied patients (45%) appeared to be a notable association. Subtle abnormalities in IgG subclasses, lymphocyte subsets and in vitro proliferative lymphocyte responses were observed. Five patients who were treated with intravenous immunoglobulin responded very well. CONCLUSION: We propose that a thorough immunological evaluation including specific antibody responses be undertaken in patients with IgM deficiency. IgM-deficient patients who present with recurrent/severe infections may benefit from immunoglobulin treatment particularly in the presence of impaired pneumococcal antibody responses.
Leman Yel; Srinivasan Ramanuja; Sudhir Gupta
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Publication Detail:
Type:  Journal Article     Date:  2009-06-04
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  150     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-15     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  291-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA.
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MeSH Terms
Antigens, Bacterial / immunology
Diagnosis, Differential
Dysgammaglobulinemia / blood,  diagnosis*,  immunology,  physiopathology,  therapy
Hypersensitivity, Immediate / blood,  diagnosis*,  immunology,  physiopathology,  therapy
Immunity, Humoral
Immunoglobulin M / blood,  deficiency
Immunoglobulins, Intravenous / therapeutic use
Middle Aged
Pneumococcal Infections / blood,  diagnosis*,  immunology,  physiopathology,  therapy
Retrospective Studies
Streptococcus pneumoniae / immunology*
Reg. No./Substance:
0/Antigens, Bacterial; 0/Immunoglobulin M; 0/Immunoglobulins, Intravenous

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