Document Detail


Clinical and immunological features in IgM deficiency.
MedLine Citation:
PMID:  19494527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: IgM deficiency is a dysgammaglobulinemia characterized by isolated low levels of serum IgM. Patients with IgM deficiency may exhibit various clinical manifestations. However, IgM deficiency still remains to be explored with regard to diagnosis and treatment. METHODS: Through a retrospective chart review, we investigated the clinical and immunological features of 15 symptomatic adult IgM-deficient patients who were referred to our immunology clinics over a 4-year period. RESULTS: The patients were comprised of 6 males and 9 females, with a mean age of 57.2 years. On initial evaluation, 12 patients (80%) presented with susceptibility to infections, 5 (33%) had atopic manifestations such as asthma and allergic rhinitis, 3 (20%) had both infections and atopy, 4 patients (28%) had fibromyalgia-like symptoms, 3 (20%) had autoimmune manifestations, and 1 patient had lymphoma. The mean serum IgM level was 27.4 mg/dl (range 14-39). Impaired specific antibody response to pneumococcal antigens in 5 out of 11 studied patients (45%) appeared to be a notable association. Subtle abnormalities in IgG subclasses, lymphocyte subsets and in vitro proliferative lymphocyte responses were observed. Five patients who were treated with intravenous immunoglobulin responded very well. CONCLUSION: We propose that a thorough immunological evaluation including specific antibody responses be undertaken in patients with IgM deficiency. IgM-deficient patients who present with recurrent/severe infections may benefit from immunoglobulin treatment particularly in the presence of impaired pneumococcal antibody responses.
Authors:
Leman Yel; Srinivasan Ramanuja; Sudhir Gupta
Related Documents :
5309797 - Altered immunoglobulin metabolism in systemic lupus erythematosus and heumatoid arthritis.
21376407 - Prevalence of comorbidities and associated cardiac diseases in patients with valve aort...
20670067 - Coeliac disease in china, a field waiting for exploration.
20214227 - Determination of advanced glycation end-products on igg in liver cirrhosis.
3415957 - Short-term effects of neodymium-yag transscleral cyclocoagulation in patients with unco...
12633637 - Home monitoring in icd therapy: future perspectives.
Publication Detail:
Type:  Journal Article     Date:  2009-06-04
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  150     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-15     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  291-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA. lyel@uci.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antigens, Bacterial / immunology
Diagnosis, Differential
Dysgammaglobulinemia / blood,  diagnosis*,  immunology,  physiopathology,  therapy
Female
Humans
Hypersensitivity, Immediate / blood,  diagnosis*,  immunology,  physiopathology,  therapy
Immunity, Humoral
Immunoglobulin M / blood,  deficiency
Immunoglobulins, Intravenous / therapeutic use
Male
Middle Aged
Pneumococcal Infections / blood,  diagnosis*,  immunology,  physiopathology,  therapy
Recurrence
Retrospective Studies
Streptococcus pneumoniae / immunology*
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Immunoglobulin M; 0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elevated concentrations of liver-expressed chemokine/CC chemokine ligand 16 in bronchoalveolar lavag...
Next Document:  Association between asthma, rhinitis and NSAID hypersensitivity in chronic urticaria patients and pr...