| Clinical and immunological features of celiac disease in patients with Type 1 diabetes mellitus. | |
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MedLine Citation:
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PMID: 21780895 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Celiac disease (CD) is one of the most frequent autoimmune disorders occurring in Type 1 diabetes mellitus (T1DM). The prevalence of CD in T1DM varies from 3 to 16%, with a mean prevalence of 8%. The clinical presentation of CD in T1DM is classified as symptomless in approximately half of cases, but a more accurate analysis often discloses a wide array of symptoms suggestive of CD. Both T1DM and CD show the same genetic background and an abnormal small intestinal immune response with inflammation and a variable grade of enteropathy. Serological screening for CD should be performed in all T1DM patients by means of antibodies to tissue transglutaminase at T1DM onset. T1DM patients found to be celiacs must be treated by a gluten-free diet. Potential CD cases (especially when asymptomatic) should be kept on a gluten-containing diet with a careful clinical and antibody follow-up, since many of them will not develop villous atrophy. |
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Authors:
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Umberto Volta; Francesco Tovoli; Giacomo Caio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of gastroenterology & hepatology Volume: 5 ISSN: 1747-4132 ISO Abbreviation: Expert Rev Gastroenterol Hepatol Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278199 Medline TA: Expert Rev Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 479-87 Citation Subset: IM |
Affiliation:
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Department of Digestive Diseases and Internal Medicine, S Orsola-Malpighi Policlinic, University of Bologna, Bologna, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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