Document Detail

Clinical and immunological evaluation of patients with mild IgG1 deficiency.
MedLine Citation:
PMID:  10540166     Owner:  NLM     Status:  MEDLINE    
Serum IgG subclass concentrations were determined in patients visiting, the pulmonology out-patient clinic with chronic respiratory tract problems. A total of 24 patients with a serum IgG1 concentration < 4.9 g/l (i.e. below the reference range) and normal values for IgG2, IgM and IgA were included. Patients with a selective IgG1 deficiency were vaccinated with a 23-valent pneumococcal polysaccharide vaccine. There were nine patients with a poor antibody response to pneumococcal capsular polysaccharide antigens. Responsiveness to protein antigens was intact in all patients. Patients with pneumonia showed a significantly lower anti-polysaccharide response in the IgG2 subclass than patients without pneumonia. Patients with recurrent sinusitis showed a significantly lower response in the IgA isotype after vaccination with pneumococcal polysaccharide vaccine compared with non-sinusitis patients. It can be concluded that patients with recurrent sinopulmonary infections and a mild IgG1 subclass deficiency have an impaired IgG1 anti-polysaccharide response, which can extend to decreased IgG2 and IgA anti-polysaccharide responses.
D A Van Kessel; P E Horikx; A J Van Houte; C S De Graaff; H Van Velzen-Blad; G T Rijkers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  118     ISSN:  0009-9104     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-19     Completed Date:  1999-11-19     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  102-7     Citation Subset:  IM    
Department of Pulmonology, Sint Antonius Hospital Nieuwegein, The Netherlands.
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MeSH Terms
Antibodies, Bacterial / blood
Bacterial Vaccines / therapeutic use
IgG Deficiency / complications,  immunology*
Immunoglobulin A / blood
Immunoglobulin G / blood*,  immunology*
Immunoglobulin M / blood
Middle Aged
Pneumococcal Vaccines
Polysaccharides, Bacterial / immunology
Respiratory Tract Infections / blood,  complications,  immunology,  prevention & control
Serologic Tests
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Vaccines; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Pneumococcal Vaccines; 0/Polysaccharides, Bacterial

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