Document Detail

Clinical and immunological effects of immunotherapy with glutaraldehyde modified house dust mite extract.
MedLine Citation:
PMID:  7840025     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to demonstrate the clinical effectiveness of treatment with specific immunotherapy using allergenic mite extracts modified with glutaraldehyde. The results showed an improvement both in clinical symptoms and a reduction in the complementary pharmacological therapy used. Several clinical "in vitro" and "in vivo" parameters were analysed during this study. The results obtained from the Nasal Challenge Test and the Skin Test (prick-test) were the most relevant. Patient tolerance to the diagnostic extract was increased in 45% of the patients, the result of which was registered in the Nasal Challenge Test. Evaluation of the results derived from the skin tests on conclusion of immunotherapy, showed a reduction in response in 55% of the patients. Progressive immunotherapeutic doses were applied at short intervals with no record of severe reactions.
A Malet; M Lluch; A L Valero; M Casanovas
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  22     ISSN:  0301-0546     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  226-32     Citation Subset:  IM    
Al-Lergo Centre, Barcelona, Spain.
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MeSH Terms
Antigens, Dermatophagoides
Child, Preschool
Cross-Linking Reagents / pharmacology*
Desensitization, Immunologic*
Glutaral / pharmacology*
Glycoproteins / drug effects,  therapeutic use*
Hypersensitivity, Immediate / etiology,  immunology,  therapy*
Immunoglobulin E / blood
Immunoglobulin G / blood
Injections, Subcutaneous
Intradermal Tests
Mites / immunology*
Nasal Provocation Tests
Treatment Outcome
Reg. No./Substance:
0/Antigens, Dermatophagoides; 0/Cross-Linking Reagents; 0/Glycoproteins; 0/Immunoglobulin G; 0/Polymers; 111-30-8/Glutaral; 37341-29-0/Immunoglobulin E

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