| Clinical and immunological characterization of patients with systemic sclerosis overlapping primary biliary cirrhosis: a comparison with patients with systemic sclerosis alone. | |
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MedLine Citation:
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PMID: 10063207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Limited cutaneous systemic sclerosis (lSSc) or CREST syndrome is sometimes complicated by primary biliary cirrhosis (PBC). To characterize the clinical and immunological features of patients with SSc overlapping PBC (SSc-PBC), the clinical and laboratory data of 11 SSc-PBC were studied. Since all of the SSc-PBC were lSSc, the features of SSc-PBC were compared with those of 266 patients with lSSc alone. The sera from SSc-PBC showed a significantly higher positivity for anti-centromere antibody (ACA) (p < 0.0005) and higher reactivity to centromere protein-C. Although SSc-PBC more frequently exhibited calcinosis and telangiectasia (p < 0.05), there was no statistical difference in other features of CREST syndrome. There was no statistical difference in other scleroderma-related features either. SSc-PBC were more frequently complicated with Sjögren syndrome (p < 0.05). The most prominent feature of SSc-PBC was a higher incidence of ACA than in lSSc alone. |
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Authors:
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S Akimoto; O Ishikawa; Y Muro; H Takagi; T Tamura; Y Miyachi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 26 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-03-17 Completed Date: 1999-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 18-22 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Gunma University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Autoantibodies / analysis Blotting, Western CREST Syndrome / complications, immunology, pathology Centromere / immunology Humans Liver Cirrhosis, Biliary / complications* Middle Aged Mitochondria / immunology Scleroderma, Systemic / complications, immunology*, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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