Document Detail

Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni.
MedLine Citation:
PMID:  11756987     Owner:  NLM     Status:  MEDLINE    
Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)-alpha, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean+/-SD, 7.8+/-7.6 microg Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean +/- SD) of TNF-alpha (1349.3+/-767.6 pg/mL), interleukin (IL)-1 (2683+/-1270 pg/mL), and IL-6 (382 +/- 52.3 pg/mL) were elevated in PBMC. Serum TNF-alpha levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-gamma levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis.
Amelia Ribeiro de Jesus; Angela Silva; Luciana B Santana; Andrea Magalhães; Adriana Almeida de Jesus; Roque Pacheco de Almeida; Marco A V Rêgo; Marcelo N Burattini; Edward J Pearce; Edgar M Carvalho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2001-12-14
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  185     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-28     Completed Date:  2002-01-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  98-105     Citation Subset:  AIM; IM    
Serviço de Imunologia, Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil.
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MeSH Terms
Acute Disease
Antigen-Antibody Complex / blood
Antigens, Helminth / blood
Brazil / epidemiology
Chronic Disease
Cytokines / secretion
Endemic Diseases
Feces / parasitology
Immunoglobulin E / blood
Leukocytes, Mononuclear / immunology
Parasite Egg Count
Schistosomiasis mansoni / epidemiology,  etiology,  immunology*
Water / parasitology
Water Supply
Grant Support
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Antigens, Helminth; 0/Cytokines; 37341-29-0/Immunoglobulin E; 7732-18-5/Water

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