Document Detail

Clinical and immunologic characterization in 26 Indian pemphigus patients.
MedLine Citation:
PMID:  24067852     Owner:  NLM     Status:  In-Data-Review    
Background:Pemphigus shows geographically variable characteristics.Objective:To study the clinical and immunologic characteristics of Indian pemphigus patients before and after treatment.Methods:Twenty-six Indian pemphigus patients were analyzed with regard to age, gender, clinical features, treatments and response, the results of histopathology, direct and indirect immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), and immunoblot analyses.Results:There were 22 pemphigus vulgaris (PV) and 4 pemphigus foliaceus (PF) patients. Direct and indirect IF was positive in 95.8% and 56% of patients, respectively. Indices of ELISA were lower in our study. Immunoblot assays detected the 130 kDa desmoglein-3 in 10 PV patients and the 160 kDa desmoglein-1 in 1 PV patient; 190 kDa periplakin was unexpectedly detected in 8 patients.Conclusion:Indian pemphigus patients showed several unique characteristics, including younger population, predominance of PV, low ELISA indices, lower sensitivity of indirect IF and immunoblotting, and the presence of the 190 kDa periplakin in nearly one-third of patients.
Daisuke Tsuruta; Amrinder J Kanwar; Keshavamurthy Vinay; Shunpei Fukuda; Hiroshi Koga; Teruki Dainichi; Chika Ohata; Norito Ishii; Takashi Hashimoto
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  17     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-09-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  321-31     Citation Subset:  IM    
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