Document Detail

Clinical and imaging features of Othello's syndrome.
MedLine Citation:
PMID:  21518145     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Our objective was to document the clinical and imaging features of Othello's syndrome (delusional jealousy).
METHODS: The study design was a retrospective case series of 105 patients with Othello's syndrome that were identified using the Electronic Medical Record system of Mayo Clinic.
RESULTS: The average age at onset of Othello's syndrome was 68 (25-94) years with 61.9% of patients being male. Othello's syndrome was most commonly associated with a neurological disorder (73/105) compared with psychiatric disorders (32/105). Of the patients with a neurological disorder, 76.7% had a neurodegenerative disorder. Seven of eight patients with a structural lesion associated with Othello's syndrome had right frontal lobe pathology. Voxel-based morphometry showed greater gray matter loss predominantly in the dorsolateral frontal lobes in the neurodegenerative patients with Othello's compared to matched patients with neurodegenerative disorders without Othello's syndrome. Treatment success was notable for patients with dopamine agonist induced Othello's syndrome in which all six patients had improvement in symptoms following decrease in medication.
CONCLUSIONS: This study demonstrates that Othello's syndrome occurs most frequently with neurological disorders. This delusion appears to be associated with dysfunction of the frontal lobes, especially the right frontal lobe.
J Graff-Radford; J L Whitwell; Y E Geda; K A Josephs
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-04-25
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  19     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-04-06     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  38-46     Citation Subset:  IM    
Copyright Information:
© 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
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MeSH Terms
Aged, 80 and over
Dopamine Agonists / adverse effects
Frontal Lobe / pathology*
Magnetic Resonance Imaging
Middle Aged
Neurodegenerative Diseases / complications,  drug therapy
Retrospective Studies
Schizophrenia, Paranoid / complications,  pathology*
Grant Support
P50 NS40256/NS/NINDS NIH HHS; R01 AG037491/AG/NIA NIH HHS; R01 AG037491-01/AG/NIA NIH HHS; R01 DC010367/DC/NIDCD NIH HHS; R01 DC010367/DC/NIDCD NIH HHS; R01 DC010367-01/DC/NIDCD NIH HHS; R01- DC010367/DC/NIDCD NIH HHS; R01-AG11378/AG/NIA NIH HHS; R21 AG038736-01/AG/NIA NIH HHS; U01 AG03949/AG/NIA NIH HHS
Reg. No./Substance:
0/Dopamine Agonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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