Document Detail

Clinical hyperthyroidism due to non-neoplastic inappropriate thyrotrophin secretion.
MedLine Citation:
PMID:  2235809     Owner:  NLM     Status:  MEDLINE    
We report a case of hyperthyroidism due to inappropriate thyrotrophin (TSH) secretion in a patient with selective pituitary resistance to thyroid hormone action. Symptoms of hyperthyroidism in patients with this disorder are usually mild, implying some peripheral tissue resistance to the metabolic effects of thyroid hormone. Our patient had unusually severe symptoms, including marked weight loss and cardiac arrythmias which required carbimazole and beta-blocker therapy for control. Somatostatin was ineffective in suppressing TSH secretion. The introduction of sensitive thyrotrophin assays should facilitate the accurate diagnosis of TSH-induced hyperthyroidism and avoid inappropriate treatment.
A W Chan; I A MacFarlane; C van Heyningen; P M Foy
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  66     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-12-12     Completed Date:  1990-12-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  743-6     Citation Subset:  IM    
Department of Endocrinology, Walton Hospital, Liverpool, UK.
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MeSH Terms
Hyperthyroidism / etiology*
Inappropriate ADH Syndrome / blood,  complications*,  drug therapy
Thyrotropin / blood
Reg. No./Substance:

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