Document Detail

Clinical, hormonal and sonographic predictors of successful RU-486-induced abortions.
MedLine Citation:
PMID:  8575686     Owner:  NLM     Status:  MEDLINE    
To evaluate which method, clinical, hormonal or sonographic, can be used as the best predictor of successful RU-486-induced abortions, 20 healthy women with fetal cardiac activity, between 6 and 9 weeks from the last menstrual period and desiring abortion, were studied. Fourteen women (70%) successfully aborted, and 6 (30%) failed to abort within 7 days following therapy. A small hematoma, seen as a localized detachment of the gestational sac, was observed in the decidua capsularis in women who aborted successfully. A significant decrease in plasma levels of estradiol and progesterone (p < 0.04) and significantly increased cortisol levels (p < 0.001) in the plasma of the 14 patients who aborted were noted by the 7th day following treatment. No significant changes were observed in the 6 nonaborting patients. In conclusion, the differences in the early sonographic findings may be helpful in the early prediction of successful RU-486 administration.
Y Menashe; D Bider; J Shalev; C Pariente; D M Serr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  40     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1995  
Date Detail:
Created Date:  1996-03-14     Completed Date:  1996-03-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  108-12     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
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MeSH Terms
Abortifacient Agents*
Abortion, Induced*
Chorionic Gonadotropin / blood
Estradiol / blood
Hemoglobins / analysis
Hydrocortisone / blood
Predictive Value of Tests
Progesterone / blood
Uterus / ultrasonography*
Reg. No./Substance:
0/Abortifacient Agents; 0/Chorionic Gonadotropin; 0/Hemoglobins; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 57-83-0/Progesterone; 84371-65-3/Mifepristone

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