Document Detail

Clinical history of efavirenz.
MedLine Citation:
PMID:  10622035     Owner:  NLM     Status:  MEDLINE    
Efavirenz (SUSTIVA, DMP 266, EFV) is a novel non-nucleoside reverse transcriptase inhibitor, which shows good inhibitory activity against HIV-1. The pharmacokinetics of efavirenz allow for once daily dosing without regard to meals of normal composition. Efavirenz is a mild inducer of CYP 3A4. Clinically significant drug interactions have been reported with medications that are metabolised via the cytochrome P450 enzymes such as indinavir and saquinavir. Results from the studies collated for submission (003, 006, 020, 024 and ACTG 364) have demonstrated the potency and durability of once daily efavirenz in combination with zidovudine (AZT) + lamivudine (3TC), indinavir (IDV), nelfinavir (NFV), IDV + 2 NRTIs, and NFV + 2 NRTIs. Efavirenz was recently approved for commercial use in the USA and has received marketing authorisation in Europe and Canada.
N Ruiz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of clinical practice. Supplement     Volume:  103     ISSN:  1368-504X     ISO Abbreviation:  Int J Clin Pract Suppl     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-02-02     Completed Date:  2000-02-02     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  9712380     Medline TA:  Int J Clin Pract Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  IM; X    
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MeSH Terms
Acquired Immunodeficiency Syndrome / drug therapy*
Anti-HIV Agents / pharmacokinetics,  therapeutic use*
Clinical Trials as Topic
Drug Interactions
Oxazines / pharmacokinetics,  therapeutic use*
Reverse Transcriptase Inhibitors / pharmacokinetics,  therapeutic use
Reg. No./Substance:
0/Anti-HIV Agents; 0/Benzoxazines; 0/Oxazines; 0/Reverse Transcriptase Inhibitors; JE6H2O27P8/efavirenz

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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