Document Detail


Clinical and histopathological study of "follicular cholangitis": Sclerosing cholangitis with prominent lymphocytic infiltration masquerading as hilar cholangiocarcinoma.
MedLine Citation:
PMID:  20880060     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aim:  Sclerosing cholangitis which mimic hilar biliary carcinoma have not been fully categorized. In this study, we investigated the clinicopathological features of sclerosing cholangitis of unknown origin, so-called "follicular cholangitis". Methods:  Patients who had undergone surgery of the proximal bile duct from 1993-2008 on suspicion of proximal bile carcinoma were evaluated. Of these, we investigated the cases compatible with follicular cholangitis. Then, we reviewed the previous reports of follicular cholangitis showing similar clinicopathological findings. Results:  Among 176 patients, two who were diagnosed with benign sclerosing cholangitis of unknown origin shared the common histopathological findings compatible with follicular cholangitis. Histopathological findings showed dense fibrosis with prominent lymph follicles and germinal centers, being appropriate for neither primary sclerosing cholangitis nor immunoglobulin G4-related sclerosing cholangitis. Review of previous published work revealed two other cases diagnosed with follicular cholangitis and showing histopathological findings similar to ours. All these cases were middle-aged patients with no history of autoimmune disease with focal strictures mainly involved in the hilar bile duct, mimicking hilar cholangiocarcinoma. Conclusion:  Benign sclerosing cholangitis has not been fully categorized, yet. Follicular cholangitis shows unique histopathological features and can be categorized as an independent entity.
Authors:
Takeo Fujita; Motohiro Kojima; Yuichiro Kato; Naoto Gotohda; Shinichiro Takahashi; Masaru Konishi; Taira Kinoshita
Publication Detail:
Type:  Journal Article     Date:  2010-09-28
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  40     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1239-47     Citation Subset:  -    
Copyright Information:
© 2010 The Japan Society of Hepatology.
Affiliation:
Division of Digestive Surgery, National Cancer Center Hospital East Division of Clinical Pathology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
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