| Clinical and histopathological features of myopathies in Japanese patients with anti-SRP autoantibodies. | |
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MedLine Citation:
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PMID: 19089533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To elucidate the clinical and histopathological features associated with autoantibodies to the signal recognition particle (SRP), we have studied 23 Japanese patients with this specificity among 3,500 patients with polymyositis/dermatomyositis and other connective tissue diseases. Anti-SRP antibodies were determined based on analysis of RNA and protein components by immunoprecipitation assays. The pathological analysis was performed by using special stainings including alkaline phosphatase, myosin ATPase, and modified Gomori trichrome stainings. Twenty-one (92%) of these 23 patients had myositis, 8 of whom (38%) required cytotoxic agents or intravenous immunoglobulin therapy in addition to corticosteroid therapy. Four patients (16%) had rheumatoid arthritis, two of whom had no features of myositis. Muscle biopsy specimens of 11 patients were examined histologically in detail. All 11 had muscle fiber necrosis and/or regeneration, but only one had infiltration of inflammatory cells. Six of the 11 (55%) patients showed type I fiber predominance by ATPase staining, while eight control myositis patients without anti-SRP antibodies did not. There was no correlation of other neurogenic features in histology with the presence of anti-SRP antibodies. These studies suggest that anti-SRP autoantibodies are most likely to be related to myopathies that are resistant to corticosteroid therapy and without inflammation histopathologically. |
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Authors:
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Tetsuya Takada; Michito Hirakata; Akira Suwa; Yuko Kaneko; Masataka Kuwana; Tadayuki Ishihara; Yasuo Ikeda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-17 |
Journal Detail:
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Title: Modern rheumatology / the Japan Rheumatism Association Volume: 19 ISSN: 1439-7595 ISO Abbreviation: Mod Rheumatol Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-02 Completed Date: 2009-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: Japan |
Other Details:
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Languages: eng Pagination: 156-64 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Asian Continental Ancestry Group Autoantibodies / blood*, isolation & purification Dermatomyositis / diagnosis, pathology Female Humans Japan Male Middle Aged Muscular Diseases / diagnosis*, pathology Polymyositis / diagnosis, pathology Signal Recognition Particle / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Signal Recognition Particle |
| Comments/Corrections | |
Erratum In:
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Mod Rheumatol. 2009;19(2):165 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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