Document Detail


Clinical and histopathological features of myopathies in Japanese patients with anti-SRP autoantibodies.
MedLine Citation:
PMID:  19089533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To elucidate the clinical and histopathological features associated with autoantibodies to the signal recognition particle (SRP), we have studied 23 Japanese patients with this specificity among 3,500 patients with polymyositis/dermatomyositis and other connective tissue diseases. Anti-SRP antibodies were determined based on analysis of RNA and protein components by immunoprecipitation assays. The pathological analysis was performed by using special stainings including alkaline phosphatase, myosin ATPase, and modified Gomori trichrome stainings. Twenty-one (92%) of these 23 patients had myositis, 8 of whom (38%) required cytotoxic agents or intravenous immunoglobulin therapy in addition to corticosteroid therapy. Four patients (16%) had rheumatoid arthritis, two of whom had no features of myositis. Muscle biopsy specimens of 11 patients were examined histologically in detail. All 11 had muscle fiber necrosis and/or regeneration, but only one had infiltration of inflammatory cells. Six of the 11 (55%) patients showed type I fiber predominance by ATPase staining, while eight control myositis patients without anti-SRP antibodies did not. There was no correlation of other neurogenic features in histology with the presence of anti-SRP antibodies. These studies suggest that anti-SRP autoantibodies are most likely to be related to myopathies that are resistant to corticosteroid therapy and without inflammation histopathologically.
Authors:
Tetsuya Takada; Michito Hirakata; Akira Suwa; Yuko Kaneko; Masataka Kuwana; Tadayuki Ishihara; Yasuo Ikeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-17
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  19     ISSN:  1439-7595     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-02     Completed Date:  2009-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  156-64     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asian Continental Ancestry Group
Autoantibodies / blood*,  isolation & purification
Dermatomyositis / diagnosis,  pathology
Female
Humans
Japan
Male
Middle Aged
Muscular Diseases / diagnosis*,  pathology
Polymyositis / diagnosis,  pathology
Signal Recognition Particle / immunology*
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Signal Recognition Particle
Comments/Corrections
Erratum In:
Mod Rheumatol. 2009;19(2):165

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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