Document Detail

Clinical and histopathologic correlation in patients with dilated cardiomyopathy. Value of force-velocity product.
MedLine Citation:
PMID:  2810763     Owner:  NLM     Status:  MEDLINE    
To evaluate the relation between cardiac function and myocardial damage in patients with dilated cardiomyopathy (DCM), we compared echocardiographic parameters and histopathologic findings of the biopsied myocardium in 50 cases with DCM. As wall motion is much influenced by the increased afterload in cases with large ventricles, we generated a new contractile parameter, Force-Velocity Product (FVP). FVP was defined as the result obtained by multiplying mean circumferential fiber shortening velocity by noninvasive end-systolic wall stress. FVP correlated with percent fibrosis in the myocardium, which was reflected by no other echocardiographic parameter. We also evaluated the prognostic values of the echocardiographic and histopathologic parameters. FVP had the highest value among them. We conclude that FVP is a very useful clinical parameter, with the further advantage of being obtained noninvasively.
H Kurozumi; Y Yokota; H Fukuzaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  30     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-12-07     Completed Date:  1989-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  431-41     Citation Subset:  IM    
First Department of Internal Medicine, Kobe University School of Medicine, Japan.
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MeSH Terms
Cardiomyopathy, Dilated / diagnosis*,  pathology
Middle Aged
Myocardial Contraction*
Myocardium / pathology*

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