Document Detail

Clinical and histological variants of rhinophyma, including nonsurgical treatment modalities.
MedLine Citation:
PMID:  11816064     Owner:  NLM     Status:  MEDLINE    
Phymas are slowly progressive, disfiguring disorders of the face and ears that represent the end stage of rosacea, a common centrofacial dermatosis. Phymas are probably caused by the sequelae of chronic edema and its related connective tissue and sebaceous gland hypertrophy. Rhinophyma is the commonest among them. Analogous swellings may occur on the chin (gnatophyma), forehead (metophyma), one or both ears (otophyma), and eyelids (blepharophyma). Although rhinophyma has been traditionally associated with alcoholism, there is no evidence to support this association. Four variants of rhinophyma (glandular, fibrous, fibroangiomatous, actinic) can be recognized on clinical and histological basis. The development of skin cancer, such as basal cell carcinoma or squamous cell carcinoma, in rhinophyma appears to be a matter of accidental coincidence of different diseases. Although phymas are best treated surgically, they may be a worthwhile indication for nonsurgical treatment modalities such as systemic isotretinoin. Phymas do not resolve spontaneously.
T Jansen; G Plewig
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Facial plastic surgery : FPS     Volume:  14     ISSN:  0736-6825     ISO Abbreviation:  Facial Plast Surg     Publication Date:  1998  
Date Detail:
Created Date:  2002-01-30     Completed Date:  2002-03-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8405303     Medline TA:  Facial Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  241-53     Citation Subset:  D    
Department of Dermatology, Ludwig-Maximillian University, Frauenlobstrasse 9-11, D-80337 Munich, Germany.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Chronic Disease
Dermatologic Agents / therapeutic use
Eye Diseases / etiology
Isotretinoin / therapeutic use
Rhinophyma / classification*,  drug therapy,  pathology*
Rosacea / classification,  complications,  drug therapy,  pathology
Sunscreening Agents / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Dermatologic Agents; 0/Sunscreening Agents; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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