Document Detail

Clinical and histological experience of labial lip biopsy in juvenile Sjögren syndrome
MedLine Citation:
PMID:  19564717     Owner:  NLM     Status:  MEDLINE    
The therapeutic efficacy of corticosteroids and immunosuppressants on secretary glands of children with Sjögren syndrome was investigated examining the lip-biopsy specimen on both lymphocyte infiltration and fibrosis. Six children with primary Sjögren syndrome and two children with lupus-associated secondary Sjögren syndrome were evaluated according to the intensity of therapy. The shorter the term of medications of corticosteroids and immunosuppressants were, the lesser the extents of lymphocyte infiltration and fibrosis were, and the lower the doses of medications were, the lesser the efficacy was. Thus, in childhood Sjögren syndrome, appropriate corticosteroids and immunosuppressants may provide the suppressive effects on the progressive inflammatory destruction of secretary glands. Further evaluation with more patients is needed to determine the inclusion criteria of these treatments for sicca syndrome, especially in cases with no other organ involvement.
Naomi Iwata; Takako Miyamae; Masako Kikuchi; Takayuki Kishi; Ryoki Hara; Utako Kaneko; Toshihiko Shinoki; Tomoyuki Imagawa; Yoshiaki Inayama; Shumpei Yokota
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Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology     Volume:  32     ISSN:  1349-7413     ISO Abbreviation:  Nihon Rinsho Meneki Gakkai Kaishi     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505992     Medline TA:  Nihon Rinsho Meneki Gakkai Kaishi     Country:  Japan    
Other Details:
Languages:  jpn     Pagination:  195-200     Citation Subset:  IM    
Deparrtment of Pediatrics, Yokohama City University.
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MeSH Terms
Lip / pathology*
Salivary Glands, Minor / pathology*
Sjogren's Syndrome / drug therapy,  pathology*

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