| Clinical and histological experience of labial lip biopsy in juvenile Sjögren syndrome | |
| | |
MedLine Citation:
|
PMID: 19564717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The therapeutic efficacy of corticosteroids and immunosuppressants on secretary glands of children with Sjögren syndrome was investigated examining the lip-biopsy specimen on both lymphocyte infiltration and fibrosis. Six children with primary Sjögren syndrome and two children with lupus-associated secondary Sjögren syndrome were evaluated according to the intensity of therapy. The shorter the term of medications of corticosteroids and immunosuppressants were, the lesser the extents of lymphocyte infiltration and fibrosis were, and the lower the doses of medications were, the lesser the efficacy was. Thus, in childhood Sjögren syndrome, appropriate corticosteroids and immunosuppressants may provide the suppressive effects on the progressive inflammatory destruction of secretary glands. Further evaluation with more patients is needed to determine the inclusion criteria of these treatments for sicca syndrome, especially in cases with no other organ involvement. |
| | |
Authors:
|
Naomi Iwata; Takako Miyamae; Masako Kikuchi; Takayuki Kishi; Ryoki Hara; Utako Kaneko; Toshihiko Shinoki; Tomoyuki Imagawa; Yoshiaki Inayama; Shumpei Yokota |
Related Documents
:
|
18984407 - New concepts in the pathogenesis of sjögren's syndrome. 20123387 - A comparison of diagnostic tools for sj?gren syndrome, with emphasis on sialography, hi... 2789657 - A postmortem study of focal adenitis in salivary and lacrimal glands. 16362447 - Seronegative sjögren syndrome with asymptomatic autoimmune sclerosing pancreatitis. 12409907 - Scoliosis in velo-cardio-facial syndrome. 20693557 - Ocular manifestations of the antiphospholipid syndrome. |
Publication Detail:
|
Type: English Abstract; Journal Article |
Journal Detail:
|
Title: Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology Volume: 32 ISSN: 1349-7413 ISO Abbreviation: Nihon Rinsho Meneki Gakkai Kaishi Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-30 Completed Date: 2009-11-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9505992 Medline TA: Nihon Rinsho Meneki Gakkai Kaishi Country: Japan |
Other Details:
|
Languages: jpn Pagination: 195-200 Citation Subset: IM |
Affiliation:
|
Deparrtment of Pediatrics, Yokohama City University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Biopsy Child Female Humans Lip / pathology* Salivary Glands, Minor / pathology* Sjogren's Syndrome / drug therapy, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of microscopic polyangiitis relapsed with diffuse alveolar hemorrhage and rapidly progressive...
Next Document: CURRENT IODINE STATUS IN TURKEY.