Document Detail

Clinical and histologic variations among thirty patients with Lucio's phenomenon and pure and primitive diffuse lepromatosis (Latapi's lepromatosis).
MedLine Citation:
PMID:  16830639     Owner:  NLM     Status:  MEDLINE    
The clinical and histologic experience with 30 patients who had Lucio's phenomenon, and pure and primitive diffuse lepromatosis (Latapi's lepromatosis) has been reviewed. The unanticipated clinical findings were a male to female ratio of nearly 1:1, a 21 month median time of onset of erythema nodosum leprosum (Type 2 reaction) after starting antibacterial treatment, and an absence of a stocking-glove pattern of anesthesia in 7 patients. The only unanticipated histologic finding was a lepromatous-granulomatous vasculitis, occurring in comparatively large vessels, or in vessels made large by pathologic changes, located near the dermal-subcutaneous interface. This finding was present in 6 of the 22 patients with histologic material available for review. In 2 of these 6 this vasculitis was identified before the onset of Lucio's phenomenon. With one conspicuous exception, the onset of treatment with a microbicidal agent was associated with a cessation of new lesions of Lucio's phenomenon within one week. Long-term morbidity, other than Type 2 reaction, was found in 22 of the 25 patients followed for more than 1.3 years. Usually this was the consequence of Latapi's lepromatosis, specifically venous insufficiency and/or loss of protective sensation, and only rarely from Lucio's phenomenon, specifically scar formation. Briefly summarized are the seven patients who had had a skin biopsy before the onset of Lucio's phenomenon, as well as the two patients who were considered to be atypical. Criteria for the diagnosis of Latapi's lepromatosis, in the absence of Lucio's phenomenon, are also considered.
Thomas H Rea; Robert S Jerskey
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association     Volume:  73     ISSN:  0148-916X     ISO Abbreviation:  Int. J. Lepr. Other Mycobact. Dis.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2006-07-11     Completed Date:  2006-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505819     Medline TA:  Int J Lepr Other Mycobact Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-88     Citation Subset:  IM    
Division of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA.
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MeSH Terms
Erythema Nodosum / pathology
Leprostatic Agents / therapeutic use
Leprosy, Lepromatous / drug therapy,  pathology*,  physiopathology*
Middle Aged
Sex Factors
Skin / pathology
Time Factors
Vasculitis / pathology
Reg. No./Substance:
0/Leprostatic Agents

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