Document Detail

Clinical heterogeneity of de novo 11q deletion chronic lymphocytic leukaemia: prognostic relevance of extent of 11q deleted nuclei inside leukemic clone.
MedLine Citation:
PMID:  23027683     Owner:  NLM     Status:  MEDLINE    
Deletion on the long arm of chromosome 11 occurs in 5-20% of chronic lymphocytic leukaemia (CLL) patients. We analysed clinical-biological characteristics of 131 CLL patients carrying 11q deletion documented before therapy (de novo 11q deleted CLL). De novo 11q deleted CLL were characterized by high frequencies of unmutated immunoglobulin variable heavy genes, multiple fluorescence in situ hybridization aberrations and lymph node involvement. Factors significantly associated with shorter time to first treatment (TTFT) were advanced Binet stages, high white blood cell count, increased β2 -microglobulin levels, 17p in addition, splenomegaly and more extensive lymphadenopathy. We found that patients with <25% 11q deleted nuclei (n = 22) experienced longer TTFT compared with patients with ≥25% 11q deleted nuclei (n = 87; median TTFT, 40 vs. 14 months, p = 0.011) and also showed better response to treatments (complete response, 50% vs. 21%, p = 0.016). The variables identified by multivariate analysis as independently associated with reduced TTFT were advanced Binet stages [hazard ratio (HR) 4.69; p < 0.001] and ≥25% 11q deleted nuclei (HR 4.73; p = 0.004). De novo 11q deleted CLLs exhibit variable clinical outcome. The percentage of deleted nuclei inside leukemic clone should be included in the prognostic definition of therapy-naïve 11q deleted CLL patients.
Roberto Marasca; Rossana Maffei; Silvia Martinelli; Stefania Fiorcari; Jenny Bulgarelli; Giulia Debbia; Davide Rossi; Francesca Maria Rossi; Gian Matteo Rigolin; Sara Martinelli; Valter Gattei; Giovanni Del Poeta; Luca Laurenti; Francesco Forconi; Marco Montillo; Gianluca Gaidano; Mario Luppi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-02
Journal Detail:
Title:  Hematological oncology     Volume:  31     ISSN:  1099-1069     ISO Abbreviation:  Hematol Oncol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2013-09-16     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  8307268     Medline TA:  Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  88-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Aged, 80 and over
Chromosome Deletion*
Chromosomes, Human, Pair 11*
Genetic Heterogeneity
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*,  pathology,  therapy
Middle Aged
Sequence Deletion
Erratum In:
Hematol Oncol. 2013 Spe;31(3):168

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