| Clinical, haematological and biochemical findings in foals with neonatal Equine herpesvirus-1 infection compared with septic and premature foals. | |
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MedLine Citation:
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PMID: 10505959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A retrospective multicentre study comparing historical, clinical, haematological, acid-base and biochemical findings of foals with Equine herpesvirus-1 (EHV-1) infection, septicaemia or prematurity was performed to determine if early diagnosis of EHV-1 foals was possible. Fifty-three foals were studied and were assigned to one of 2 groups: herpes positive (n = 14) or herpes negative (n = 39). The latter group included 20 septic, 11 premature, and 8 premature and septic foals. The presence of herpes antigen was confirmed by immunoperoxidase histochemical staining of tissues from necropsied foals. A nonparametric statistical analysis followed by a backwards elimination logistic regression was performed to establish a model at a P value of <0.05. All herpes positive foals died, while 47% (9/19) of the septic foals survived. Based upon our analysis, herpes positive foals were more likely to have total white blood cell counts less than 3 x 10(9)/l and to be icteric as compared to the septic and premature foals. Despite profound hepatic necrosis in the herpes positive foals, liver enzymes were not elevated and were not significantly different from the controls. |
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Authors:
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G Perkins; D M Ainsworth; H N Erb; F Del Piero; M Miller; P A Wilkins; J Palmer; M Frazer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: Equine veterinary journal Volume: 31 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-12-30 Completed Date: 1999-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 422-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Animals Animals, Newborn Antigens, Viral / analysis Blood Chemical Analysis / veterinary Blood Gas Analysis / veterinary Diagnosis, Differential Gestational Age Herpesviridae Infections / diagnosis, metabolism, veterinary* Herpesvirus 1, Equid* / immunology Horse Diseases / blood, diagnosis*, metabolism Horses Leukocyte Count / veterinary Liver / enzymology, pathology Logistic Models Physical Examination / veterinary Retrospective Studies Risk Factors Sepsis / diagnosis, metabolism, veterinary |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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