Document Detail


Clinical, haematological and biochemical findings in foals with neonatal Equine herpesvirus-1 infection compared with septic and premature foals.
MedLine Citation:
PMID:  10505959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A retrospective multicentre study comparing historical, clinical, haematological, acid-base and biochemical findings of foals with Equine herpesvirus-1 (EHV-1) infection, septicaemia or prematurity was performed to determine if early diagnosis of EHV-1 foals was possible. Fifty-three foals were studied and were assigned to one of 2 groups: herpes positive (n = 14) or herpes negative (n = 39). The latter group included 20 septic, 11 premature, and 8 premature and septic foals. The presence of herpes antigen was confirmed by immunoperoxidase histochemical staining of tissues from necropsied foals. A nonparametric statistical analysis followed by a backwards elimination logistic regression was performed to establish a model at a P value of <0.05. All herpes positive foals died, while 47% (9/19) of the septic foals survived. Based upon our analysis, herpes positive foals were more likely to have total white blood cell counts less than 3 x 10(9)/l and to be icteric as compared to the septic and premature foals. Despite profound hepatic necrosis in the herpes positive foals, liver enzymes were not elevated and were not significantly different from the controls.
Authors:
G Perkins; D M Ainsworth; H N Erb; F Del Piero; M Miller; P A Wilkins; J Palmer; M Frazer
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Equine veterinary journal     Volume:  31     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  422-6     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853, USA.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium
Animals
Animals, Newborn
Antigens, Viral / analysis
Blood Chemical Analysis / veterinary
Blood Gas Analysis / veterinary
Diagnosis, Differential
Gestational Age
Herpesviridae Infections / diagnosis,  metabolism,  veterinary*
Herpesvirus 1, Equid* / immunology
Horse Diseases / blood,  diagnosis*,  metabolism
Horses
Leukocyte Count / veterinary
Liver / enzymology,  pathology
Logistic Models
Physical Examination / veterinary
Retrospective Studies
Risk Factors
Sepsis / diagnosis,  metabolism,  veterinary
Chemical
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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