Document Detail

Clinical, genetic, and histologic features of the trichoonychodental (TOD) syndrome.
MedLine Citation:
PMID:  211469     Owner:  NLM     Status:  MEDLINE    
A syndrome of scanty, fine, curled hair, thin dysplastic nails, taurodontic molars, hypoplastic-hypomature enamel, dysplasia of dentin, and hypohidrosis segregating as an autosomal dominant trait is described in a Japanese family. The patients received repeated doses of tetracycline during odontogenesis which fortuitously assisted in interpreting the pathogenesis of the dentin defect. The condition was previously described as familial congenital ectodermal dysplasia by Westerholm and as odontogenesis imperfecta by Siirilä and Heikinheimo. It is suggested that the name trichoonychodental (TOD) syndrome is a better descriptive term for the condition.
H Koshiba; O Kimura; M Nakata; C J Witkop
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, and oral pathology     Volume:  46     ISSN:  0030-4220     ISO Abbreviation:  Oral Surg. Oral Med. Oral Pathol.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-11-29     Completed Date:  1978-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376406     Medline TA:  Oral Surg Oral Med Oral Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  376-85     Citation Subset:  D; IM    
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MeSH Terms
Chromosome Aberrations
Chromosome Disorders
Dentin Dysplasia
Ectodermal Dysplasia / genetics*,  pathology
Microscopy, Fluorescence
Odontodysplasia / genetics*,  pathology
Sweat Glands / abnormalities
Tetracyclines / adverse effects
Tooth Abnormalities / genetics
Reg. No./Substance:

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