Document Detail

Clinical and genetic aspects of juvenile absence epilepsy.
MedLine Citation:
PMID:  7964917     Owner:  NLM     Status:  MEDLINE    
Fifteen patients aged 11-25 years (mean 15.37, SD 3.89) suffering from juvenile absence epilepsy are presented. Only 3 (20%) had absences (AS) as the only seizure type, 12 (80%) had associated generalized tonic-clinic seizures (GTCS) and in the remaining 3 with absences and GTCS there was also sporadic myoclonus. We found a higher frequency of AS in our patients by clinical history and video-EEG than has been previously reported. In our patients the mean age of onset in years was 11.4, SD 1.24 for AS, 13.12, SD 2.31 for GTCS and 12.5, SD 2.18 for myoclonus. The correct diagnosis was not made on referrals for any of the patients. It took an average of 3-5.5 years from the onset of the AS (range: 6-120 months) and 2 years from the occurrence of GTCS (average: 1-72 months) to make the correct diagnosis and institute proper treatment, which was valproic acid (VPA). The GTCS were controlled in all patients whereas AS continued in 6 (40%), but to a significantly lesser degree. The frequency and the duration of the GTCS before the start of VPA treatment seemed to have an adverse effect on AS control. We documented no circadian rhythm in either AS or the GTCS, except in 2 patients who had AS and GTCS mainly when they awoke in the morning. The sample size was too small to perform a proper genetic study, though a positive history of epilepsies of mixed types was obtained in 35.7% of the parents and the siblings of the probands.
T Obeid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  241     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-12-06     Completed Date:  1994-12-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  487-91     Citation Subset:  IM    
Division of Neurology and Clinical Neurophysiology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
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MeSH Terms
Epilepsy, Absence / drug therapy,  genetics*,  physiopathology*
Seizures / classification,  pathology
Valproic Acid / therapeutic use
Reg. No./Substance:
99-66-1/Valproic Acid

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