Document Detail

Clinical and functional effects of restrictive mitral annuloplasty at midterm follow-up in heart failure patients.
MedLine Citation:
PMID:  21095335     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Restrictive mitral annuloplasty (RMA) is increasingly applied to treat functional mitral regurgitation in heart failure patients. Previous studies indicated beneficial clinical effects with low recurrence rates. However, the underlying pathophysiology is complex and outcome in terms of left ventricular function is not well known. We investigated chronic effects of RMA on ventricular function in relation to clinical outcome.
METHODS: Heart failure patients (n = 11) with severe mitral regurgitation scheduled for RMA were analyzed at baseline (presurgery) and midterm follow-up by invasive pressure-volume loops, using conductance catheters. Clinical performance was evaluated by New York Heart Association class, quality-of-life-score, and 6-minute hall-walk-test.
RESULTS: All patients were alive without recurrence of mitral regurgitation at follow-up (9.4 ± 4.1 months). Clinical parameters improved significantly (all p < 0.05). Global cardiac function, assessed by cardiac output, stroke volume, and stroke work did not change after RMA. Reverse remodeling was demonstrated by decreased end-systolic and end-diastolic volumes (16% and 11%, both p < 0.001). Systolic function improved, evidenced by increased ejection fraction (0.32 ± 0.05 to 0.36 ± 0.07, p = 0.001) and leftward shift of the end-systolic pressure-volume relation (ESV(100): 116 ± 43 to 74 ± 26 mL, p < 0.001). Diastolic function, however, demonstrated impairment by increased tau (69 ± 13 to 80 ± 14 ms, p < 0.001) and stiffness constant (0.022 ± 0.022 to 0.031 ± 0.028 mL(-1), p = 0.001).
CONCLUSIONS: Restrictive mitral annuloplasty significantly improved clinical status without recurrence of mitral regurgitation at midterm follow-up in patients with heart failure. Hemodynamic analyses demonstrated significant reverse remodeling with unchanged global function and improved systolic function, but some signs of diastolic impairment. Overall, RMA appears an appropriate therapy for patients with dilated cardiomyopathy and functional mitral regurgitation.
Ellen A ten Brinke; Robert J Klautz; Sven A Tulner; Harriette F Verwey; Jeroen J Bax; Victoria Delgado; Eduard R Holman; Martin J Schalij; Ernst E van der Wall; Jerry Braun; Michel I Versteegh; Robert A Dion; Paul Steendijk
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  90     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1913-20     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Cardiac Valve Annuloplasty / methods*
Echocardiography, Doppler, Color
Echocardiography, Transesophageal
Exercise Test
Follow-Up Studies
Heart Failure / complications,  mortality,  surgery*
Heart Ventricles / physiopathology,  ultrasonography
Mitral Valve Insufficiency / complications,  physiopathology,  surgery*
Quality of Life*
Stroke Volume / physiology*
Time Factors
Treatment Outcome
Comment In:
Ann Thorac Surg. 2010 Dec;90(6):1920-1   [PMID:  21095336 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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